STAT3 Promotes Human Lingual Squamous Cell Carcinoma Invasion and Metastasis

Abstract

Abstract: Objective: To investigate the expression of signal transducers and activators of transcription 3 (Stat3) in human lingual squamous cell carcinoma and to evaluate the role of STAT3 for tumor cell invasion and metastasis. Methods: The immunohistochemistry method was used to detect the expression of STAT3 in human lingual squamous cell carcinoma. The human lingual squamous cell carcinoma cell line, Tca-8113 cells were transfected with STAT3 small interfering RNA(siRNA). Transwell assay was used to study cell invasion. Results: There was a significant correlation between STAT3 expression and stages (P=0.029) and lymph node metastasis (P=0.009). The specific knockdown of STAT3 by RNA interference strongly inhibited the motile and invasion activity of tumor cells. Conclusion: STAT3 promotes human lingual squamous cell carcinoma invasion and metastasis. STAT3 siRNA can inhibit the invasion ability of tumor cells.

Key words: Lingual squamous cell carcinoma, STAT3, siRNA

CLC Number:

R739.8

ZHAO Yan, ZHANG Bi, CHEN Qi, et al. STAT3 Promotes Human Lingual Squamous Cell Carcinoma Invasion and Metastasis[J]. Journal of Oral Science Research, 2015, 31(7): 688-690.

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