Abstract: Objective: To explore the clinicopathological features, diagnosis, and treatment of giant cell granuloma. Methods: The diagnosis and treatment of one case of auriculotemporal giant cell granuloma treated in the Department of Oral and Maxillofacial Surgery, Lanzhou Military Region General Hospital in March 2017 were retrospectively analyzed. And the relevant literatures were reviewed. Results: Giant cell granuloma was a rare non-neoplastic benign lesion with local invasiveness. Histopathological features were fibrous of proliferated collagen tissue, where multicore giant cells and hemosiderin could be seen, and more inflammatory cells infiltrated. Conclusion: Giant cell granuloma is a kind of non-tumor pathological change. It is rare in clinical and difficult to diagnose, which needs the combination of clinical and pathological analysis. Postoperative radiotherapy is an effective treatment method after the complete remove of lesion part.

Key words: Giant cell granuloma, Clinical pathology , Diagnosis, Differential diagnosis, Treatment