Abstract: Objective: To investigate the clinicopathological features, diagnosis, and differential diagnosis of pleomorphic hyalinized angiectatic tumor of soft tissue. Methods: Pleomorphic hyalinized angiectatic tumors of soft tissue were analyzed and reviewed. Results: Tumors were nodular, which had clear boundaries with the surrounding tissue. Tumors' diolame was complete or incomplete. Under the microscope, thin-walled dilated vascular wall were seen, which had fibrinous substance deposition and thrombus. Between vessels pleomorphic tumor cells were seen. The mitotic figure was rare. Immunohistochemical staining showed CD34(+), Vimentin(+), BCL-2 (Partial+),and Ki-67 (+3%). Conclusion: Pleomorphic hyalinized angiectatic tumor of soft tissue is a rare tumor which has good prognosis. However, it needs to be identified with multiple tumors. Immunohistochemical markers may assist the diagnosis.

Key words: pleomorphic hyalinized angiectatic tumor of soft tissue, diagnosis, differential