Modulation of Osteoimmune Microenvironment by Adding Bioactive Elements to Implants Surface

doi:10.13701/j.cnki.kqyxyj.2020.10.005

Abstract

Abstract: Osteoimmune microenvironment has profound influence on initial osseointegration, which is closely related to implants surface characteristics. The high diversity and plasticity of immune cells make it possible to manipulate the immune cells response and cytokines expression, thus modulating the osteoimmune microenvironment. Modified by the bioactive elements, such as Zn, Sr, Si, the implants surface can stimulate the osteogenic differentiation of bone marrow mesenchymal stem cells and increase the expression of anti-inflammatory cytokines in immune cells. Based on these complex interactions, this review discusses the strategies by adding bioactive elements to implants surface and highlights the possible underlying mechanisms of osteoimmunomodulation in order to guide the development of advanced implants.

Key words: implant, immune microenvironment, bioactive elements, osseointegration

FU Wenqi, LIU Huiying. Modulation of Osteoimmune Microenvironment by Adding Bioactive Elements to Implants Surface[J]. Journal of Oral Science Research, 2020, 36(10): 908-911.

References

[1] Liu K, Zhang H, Lu M, et al. Enhanced bioactive and osteogenic activities of titanium by modification with phytic acid and calcium hydroxide [J]. Appl Surf Sci, 2019, 478:162-175.
[2] Qiu J, Liu L, Chen B, et al. Graphene oxide as a dual Zn/Mg ion carrier and release platform: Enhanced osteogenic activity and antibacterial properties [J]. J Mat Chem B, 2018, 6(13):2004-2012.
[3] Franz S, Rammelt S, Scharnweber D, et al. Immune responses to implants-a review of the implications for the design of immunomodulatory biomaterials [J]. Biomaterials, 2011, 32(28):6692-6709.
[4] Terashima A, Takayanagi H. Overview of osteoimmunology [J]. Calcif Tissue Int, 2018, 102(5):503-511.
[5] Zhang R, Liu X, Xiong Z, et al. The immunomodulatory effects of Zn-incorporated micro/nanostructured coating in inducing osteogenesis [J]. Artif Cells Nanomed Biotechnol, 2018, 46(sup1):1123-1130.
[6] Limmer A, Wirtz DC. Osteoimmunology: Influence of the immune system on bone regeneration and consumption [J]. Z Orthop Unfall, 2017, 155(3):273-280.
[7] 陈江,周麟,陈旭晞.骨免疫调节机制对种植体骨结合及骨生物材料引导骨再生的影响[J].口腔疾病防治, 2018, 26(10):613-620.
[8] Arno MC, Williams RJ, Bexis P, et al. Exploiting topology-directed nanoparticle disassembly for triggered drug delivery [J]. Biomaterials, 2018, 180:184-192.
[9] Wang G, Li J, Zhang W, et al. Magnesium ion implantation on a micro/nanostructured titanium surface promotes its bioactivity and osteogenic differentiation function[J]. Int J Nanomedicine, 2014, 9:2387-2398.
[10] Hojyo S, Fukada T. Zinc transporters and signaling in physiology and pathogenesis [J]. Arch Biochem Biophys, 2016, 611:43-50.
[11] Zhang W,Zhao FJ,Huang DQ,et al. Strontium-substituted sub-micron bioactive glasses modulate macrophage responses for improved bone regeneration [J]. ACS Appl Mater Interfaces,2016,8(45):30747-30458.
[12] Chen Z, Yi D, Zheng X, et al. Nutrient element-based bioceramic coatings on titanium alloy stimulating osteogenesis by inducing beneficial osteoimmmunomodulation [J]. J Mat Chem B, 2014, 2(36):6030-6043.
[13] Gorbet M, Sperling C, Maitz MF, et al. The blood compatibility challenge. Part 3: Material associated activation of blood cascades and cells [J]. Acta Biomater, 2019, 94:25-32.
[14] Bastian OW, Koenderman L, Alblas J, et al. Neutrophils contribute to fracture healing by synthesizing fibronectin+ extracellular matrix rapidly after injury [J]. Clin Immunol, 2016,164:78-84.
[15] Das A, Sinha M, Datta S, et al. Monocyte and macrophage plasticity in tissue repair and regeneration [J]. Am J Pathol, 2015, 185(10):2596-2606.
[16] Chen Z, Bachhuka A, Wei F, et al. Nanotopography-based strategy for the precise manipulation of osteoimmunomodulation in bone regeneration [J]. Nanoscale, 2017, 9(46):18129-18152.
[17] Wu XQ, Dai Y, Yang Y, et al. Emerging role of micrornas in regulating macrophage activation and polarization in immune response and inflammation [J]. Immunology, 2016, 148(3):237-248.
[18] Spiller KL, Nassiri S, Witherel CE, et al. Sequential delivery of immunomodulatory cytokines to facilitate the M1-to-M2 transition of macrophages and enhance vascularization of bone scaffolds [J]. Biomaterials, 2015, 37:194-207.
[19] Liu W, Li J, Cheng M, et al. Zinc-modified sulfonated polyetheretherketone surface with immunomodulatory function for guiding cell fate and bone regeneration [J]. Adv Sci (Weinh), 2018, 5(10):1800749.
[20] Li B, Cao H, Zhao Y, et al. In vitro and in vivo responses of macrophages to magnesium-doped titanium [J]. Sci Rep, 2017, 7:42707-42718.
[21] Li X, Huang Q, Liu L, et al. Reduced inflammatory response by incorporating magnesium into porous TiO₂ coating on titanium substrate [J]. Colloids Surf B Biointerfaces, 2018, 171:276-284.
[22] Buache E, Velard F, Bauden E, et al. Effect of strontium-substituted biphasic calcium phosphate on inflammatory mediators production by human monocytes [J]. Acta Biomater, 2012, 8(8):3113-3119.
[23] Grandjean-Laquerriere A, Laquerriere P, Jallot E, et al. Influence of the zinc concentration of solgel derived zinc substituted hydroxyapatite on cytokine production by human monocytes in vitro [J]. Biomaterials, 2006, 27(17):3195-3200.
[24] Wu C, Chen Z, Yi D, et al. Multidirectional effects of Sr^-, Mg^-, and Si^-containing bioceramic coatings with high bonding strength on inflammation, osteoclastogenesis, and osteogenesis [J]. ACS Appl Mater Interfaces, 2014, 6(6):4264-4276.
[25] Yuan X, Cao H, Wang J, et al. Immunomodulatory effects of calcium and strontium codoped titanium oxides on osteogenesis [J]. Front Immunol, 2017, 8:1196-1210.
[26] von Bülow V, Rink L, Haase H. Zinc-mediated inhibition of cyclic nucleotide phosphodiesterase activity and expression suppresses TNF-α and IL-1β production in monocytes by elevation of guanosine 3′,5′-cyclic monophosphate [J]. J Immunol, 2005, 175(7):4697-4705.
[27] D'Onofrio A, Kent NW, Shahdad SA, et al. Development of novel strontium containing bioactive glass based calcium phosphate cement [J]. Dent Mater, 2016, 32(6):703-712.
[28] Römer P, Desaga B, Proff P, et al. Strontium promotes cell proliferation and suppresses IL-6 expression in human PDL cells[J]. Ann Anat, 2012, 194(2):208-211.
[29] Huang Q, Li X, Elkhooly TA, et al. The osteogenic, inflammatory and osteo-immunomodulatory performances of biomedical Ti-Ta metal-metal composite with Ca- and Si-containing bioceramic coatings [J]. Colloids Surf B Biointerfaces, 2018, 169:49-59.
[30] Yao X, Niu X, Ma K, et al. Graphene quantum dots-capped magnetic mesoporous silica nanoparticles as a multifunctional platform for controlled drug delivery, magnetic hyperthermia, and photothermal therapy [J]. Small,2017,13(2).
[31] Huang P, Chen Y, Lin H, et al. Molecularly organic/inorganic hybrid hollow mesoporous organosilica nanocapsules with tumor-specific biodegradability and enhanced chemotherapeutic functionality [J]. Biomaterials, 2017, 125:23-37.
[32] Chen Z, Han S, Shi M, et al. Immunomodulatory effects of mesoporous silica nanoparticles on osteogenesis: From nanoimmunotoxicity to nanoimmunotherapy [J]. Appl Mater Today, 2018, 10:184-193.
[33] Zhao Y, Wang CL, Li RM, et al. Wnt5a promotes inflammatory responses via nuclear factor κB (NF-κB) and mitogen-activated protein kinase (mapk) pathways in human dental pulp cells [J]. J Biol Chem, 2014, 289(30):21028-21039.
[34] Lu X, Li K, Xie Y, et al. Improved osteogenesis of boron incorporated calcium silicate coatings via immunomodulatory effects [J]. J Biomed Mater Res A, 2019, 107(1):12-24.