Research Progress of MicroRNA-155 in Regulating Bone Metabolism

doi:10.13701/j.cnki.kqyxyj.2020.11.002

Abstract

Abstract: Normal bone metabolism depends on a delicate balance between bone formation and bone resorption, which leads to a variety of bone-related diseases after break. As post-transcriptional factors, microRNAs are involved in the control of bone metabolism. Abnormalities in the function of microRNAs can also cause pathological changes in osseous tissue. As a potential target for the treatment of bone-related diseases, it has considerable application prospects in future clinical treatment. MicroRNA-155 is one of the most studied microRNAs, and its role in regulating bone metabolism has gradually been illustrated. This article reviews the concrete mechanism of microRNA-155 in regulating bone metabolism.

Key words: microRNA-155, bone metabolism, osteoblastic differentiation, osteoclastic differentiation

ZHANG Chengxiaoxue, ZHAO Qing. Research Progress of MicroRNA-155 in Regulating Bone Metabolism[J]. Journal of Oral Science Research, 2020, 36(11): 992-995.

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