Research Progress of Metal-organic Frameworks in the Field of Periodontitis

doi:10.13701/j.cnki.kqyxyj.2025.08.001

Abstract

Abstract: Metal-organic frameworks (MOFs) are a new type of solid crystalline porous functional materials, which are composed of organic ligands and coordinated metal ions/ion clusters. MOFs are widely used in biomedical fields, including drug delivery, implant surface coating modification, gas storage, sensing, and biological imaging. Periodontitis is a chronic inflammatory disease caused by periodontal pathogens, genetic susceptibility, host im-mune response, and other factors. This article reviews the research progress of MOFs in the field of periodontitis from four aspects: synthesis strategy of MOFs, drug loading strategy, types of MOFs related to periodontitis, and their mechanisms of action in periodontitis.

Key words: metal-organic framework, periodontitis, preparation of MOFs, biomedical properties of MOFs

JIANG Zhen, LIU Zhihui. Research Progress of Metal-organic Frameworks in the Field of Periodontitis[J]. Journal of Oral Science Research, 2025, 41(8): 641-646.

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