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Research Progress of Metal-organic Frameworks in the Field of Periodontitis JIANG Zhen, LIU Zhihui 2025, 41(8): 641-646.  DOI: 10.13701/j.cnki.kqyxyj.2025.08.001 Abstract ( 186 )   PDF (1297KB) ( 113 )   Metal-organic frameworks (MOFs) are a new type of solid crystalline porous functional materials, which are composed of organic ligands and coordinated metal ions/ion clusters. MOFs are widely used in biomedical fields, including drug delivery, implant surface coating modification, gas storage, sensing, and biological imaging. Periodontitis is a chronic inflammatory disease caused by periodontal pathogens, genetic susceptibility, host im-mune response, and other factors. This article reviews the research progress of MOFs in the field of periodontitis from four aspects: synthesis strategy of MOFs, drug loading strategy, types of MOFs related to periodontitis, and their mechanisms of action in periodontitis. References | Related Articles | Metrics

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Research Progress on Bone Defect of Adjacent Teeth after Mandibular Wisdom Tooth Extraction YUAN Haoxuan, ZHAO Lijuan 2025, 41(8): 647-651.  DOI: 10.13701/j.cnki.kqyxyj.2025.08.002 Abstract ( 191 )   PDF (808KB) ( 86 )   The third molar in the lower jaw is the most frequently impacted tooth, with an incidence reaching up to 64.5%. The lower third molar typically causes damage to the periodontal tissue of adjacent teeth. In recent years, research on the dental alveolar bone defects in adjacent teeth following the extraction of impacted lower third molars has gradually drawn attention. Studies have revealed that the alveolar bone defects in adjacent teeth after the extraction of impacted lower third molars are influenced by various factors, such as the patient's age, the periodontal health status before the operation, the type of impacted lower third molar, and the extraction method. There are numerous forms of assessment and postoperative intervention for the alveolar bone defects in adjacent teeth after the extraction of impacted lower third molars. However, the existing methods and measures still have deficiencies, and more research is required to obtain more accurate assessment methods for bone defects and clear restoration standards. This article aims to summarize the research progress regarding the influencing factors, assessment methods, and postoperative treatment plans for the alveolar bone defects in adjacent teeth after the extraction of impacted lower third molars. References | Related Articles | Metrics

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Clinical Application of Photobiomodulation Therapy in Burning Mouth Syndrome ZHANG Jinlian, ZONG Juanjuan 2025, 41(8): 652-656.  DOI: 10.13701/j.cnki.kqyxyj.2025.08.003 Abstract ( 145 )   PDF (999KB) ( 73 )   Burning mouth syndrome is a chronic idiopathic pain disorder, the etiology and pathogenesis of which are still unclear, making clinical diagnosis and treatment difficult. At present, the clinical treatments mainly focus on removing possible local or systemic factors, explaining the condition, and psychological counseling, supplemented by medication to alleviate symptoms and improve the quality of life, such as oryzanol, mecobalamin, and psychotropic drugs, etc. However, there may be risks such as long-term administration of medication, uncertainty of efficacy, and side effects of medication. In recent years, photobiomodulation therapy has been gradually introduced into the treatment of burning mouth syndrome as a non-invasive therapy without obvious side effects, and has achieved certain efficacy, and the related studies have increased over the years. Therefore, this paper reviews the mechanism of action, therapeutic parameters, efficacy, and risk of photobiomodulation therapy in burning mouth syndrome. References | Related Articles | Metrics

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E3 Ubiquitin Ligase March6 Suppresses Odontoblast Differentiation and Dentinogenesis FENG Hao, YUAN Guohua 2025, 41(8): 657-663.  DOI: 10.13701/j.cnki.kqyxyj.2025.08.004 Abstract ( 114 )   PDF (8207KB) ( 66 )   Objective: To investigate the role of E3 ubiquitin ligase March6 in odontoblast differentiation and dentinogenesis. Methods: Immunohistochemistry (IHC) staining was performed on mouse tooth sections at different developmental stages to determine the spatiotemporal expression pattern of March6. March6 was knocked down in mouse dental papilla cells (mDPCs) in vitro, followed by mineralization induction. Quantitative real-time PCR, western blot, alkaline phosphatase (ALP) staining, and alizarin red S staining were subsequently performed to evaluate the effect of March6 on the odontoblastic differentiation potential of mDPCs. Prx1cre mice were crossed with March6flox/flox mice to generate conditional knockout (cKO) mice with mesenchyme-specific deletion of March6 in the dental tissue (March6 cKO, Prx1cre;March6flox/flox). Specific deletion of March6 was validated by IHC. Mandibles from postnatal day 10 (PN10) March6 cKO and littermate control mice were analyzed by hematoxylin and eosin staining and micro-computed tomography (micro-CT) to evaluate the in vivo effect of March6 on dentinogenesis. Results: March6 exhibited low expression in the dental mesenchyme of embryonic mice, while high expression was observed in odontoblasts after their differentiation. Knockdown of March6 in mDPCs significantly upregulated the mRNA and protein levels of Dmp1 and Dspp during odontoblastic differentiation. Furthermore, ALP activity and calcified nodule formation were markedly increased in March6 deficient cells. Histological analysis and micro-CT imaging revealed a significantly thicker dentin layer in March6 cKO mice compared with littermate controls. Conclusion: The E3 ubiquitin ligase March6 negatively regulates odontoblast differentiation and dentinogenesis. References | Related Articles | Metrics

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Role of Dental Pulp Stem Cells Conditioned Medium in Pulp Regeneration GAO Jing, WANG Yuhan, YUAN Shasha, CHEN Yao, LI Lu, SHEN Jing 2025, 41(8): 664-671.  DOI: 10.13701/j.cnki.kqyxyj.2025.08.005 Abstract ( 178 )   PDF (4356KB) ( 58 )   Objective: To explore the role of dental pulp stem cells conditioned medium (DPSCs-CM) in dental pulp regeneration and related mechanisms. Methods: DPSCs were stimulated with DPSCs-CM for 1, 3, and 5 days, and its effect on DPSCs proliferation was detected using cell counting kit-8 (CCK-8). Alkaline phosphatase (ALP) content and mineralization deposition level were observed by ALP staining and alizarin red staining. The expression level of cellular osteogenic marker genes was detected using qRT-PCR. The formation of vascularization was observed using the in vitro angiogenic assay. In the nude mouse model, human tooth root fragments were implanted subcutaneously in nude mice, and pulp regeneration was observed by histologic evaluation. Meanwhile, the protein regulation mechanism of DPSCs-CM on cell differentiation during dental pulp regeneration was deeply explored by analyzing its protein profile. Results: DPSCs-CM not only promoted the proliferation of DPSCs, but also their odontogenic differentiation properties. Compared with the control group, the DPSCs+5 d CM group induced after 4 weeks produced a more mature pulp-like structure. DPSCs-CM contained more odontogenic and angiogenic factors. Conclusion: DPSCs-CM positively promoted DPSCs proliferation, dentinogenic differentiation, and angiogenesis. These findings suggest a potential benefit of DPSCs-CM in the regeneration of dental pulp tissue. References | Related Articles | Metrics

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Retrospective Study on Effect of Le-Fort Ⅰ Sagittal Anterior Displacement of Maxilla on Anatomic Morphology of Nasal Base in Patients with Skeletal Class Ⅲ LV Xin, LI Jingyi, ZHANG Qian, XIA Chengwan, WANG Yuxin, YANG Xudong 2025, 41(8): 672-678.  DOI: 10.13701/j.cnki.kqyxyj.2025.08.006 Abstract ( 97 )   PDF (2187KB) ( 41 )   Objective: To investigate the changes in soft tissue morphology of the nasal base of patients with bony category Ⅲ by maxillary anterior displacement distance during orthognathic surgery. Methods: Twenty-four patients who underwent Le-Fort Ⅰ osteotomy anteriorly at the Stomatological Hospital affiliated to the School of Medicine of Nanjing University from February 2022 to February 2024 were collected. Spiral CT images were collected from 1 week preoperatively and more than 6 months postoperatively, and 3D reconstruction and alignment were performed by Mimics and 3-Matic software to delineate the paranasal and subnasal areas. The changes in the soft tissue line spacing, angulation, volume, and curvature in each subzone were measured. Results: The maxillary anterior displacement distance was (4.09±1.35) mm. (1) Paranasal region: the width of the nasal flank and nasal base increased by (2.50±0.99) mm and (3.37±1.42) mm; the protuberance of the right nasal flank and nasal base increased by (4.03±1.08) mm and (3.80±1.23) mm; the protuberance of the left nasal flank and nasal base increased by (3.86±1.46) mm and (3.46±1.03) mm; left and right cheek prominence increased by (2.41±0.97) mm and (2.28±0.93) mm; on the right side, the angle between the line from the point of the alar base to the infraorbital point and the coronal plane, the angle between the line from the point of the alar base to the subnasal point and the coronal plane, the angle between the line from the point of the alar base to the protuberant point of cheek and the orbital auricular plane increased by (6.69±2.47)°, (7.93±15.96)°, and (13.17±14.16)°; on the left side, the corresponding angles increased (6.01±1.92)°, (6.45±15.05)°, and (12.52±13.07)°, respectively; the volume of paranasal region in the right and left increased (1289.65±538.64) mm3 and (1297.78±589.29) mm3; the curvature of paranasal regions in the right and left increased by (0.08±0.05)/mm and (0.07±0.04)/mm; and the changes of curvature in the right and left paranasal regions were 0.24±0.12 and 0.23±0.09. (2) Subnasal region: subnasal length, subnasal protuberance, and soft tissue A-point protuberance increased (0.86±0.91) mm, (2.52±1.87) mm, and (3.68±1.49) mm; nasal length decreased (1.31±0.90) mm; supra-nasolabial angle increased (4.35±2.19)°, and facial protuberance angle decreased (9.26±4.35)°; subnasal region volume increased (1933.00±740.30) mm3; curvature of the subnasal region increased (0.11±0.09)/mm, and the rate of change was 0.38±0.20. Conclusion: After maxillary advancement, nasal alar increased, nasal length decreased, subnasal length increased, and soft tissue protrusion increased. The curvature change rates of the paranasal and subnasal areas were maintained at 0.2-0.3 and 0.4, respectively. The forward displacement operation can effectively improve the nasal basal depression. References | Related Articles | Metrics

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A Prospective Clinical Study on Effects of Two Kinds of Gingival Flap Suture on The Complications After Extraction of Bone Embedded Third Molar LIU Xiangqi, WU Jiashun, LIU Yuhao, CHEN Jianghai, LUO Xueting, YANG Xin, KUANG Shijun 2025, 41(8): 679-684.  DOI: 10.13701/j.cnki.kqyxyj.2025.08.007 Abstract ( 109 )   PDF (1970KB) ( 199 )   Objective: To evaluate the effect of two kinds of gingival flap suture on the complications after extraction of bone embedded mandibular third molar (BeM3M). Methods: 376 BeM3M were divided into two groups in a prospective, randomized controlled, and single-blind design. In the control group, 197 BeM3M were extracted, and the gingival flap was closed suture (primary closure). In the experimental group, 179 BeM3M were removed, part of the gingival flap tissue was removed, and open drainage suture (secondary closure) was performed. Postoperative bleeding and infection, postoperative reaction, delayed infection, and distal periodontal probing depth of mandibular second molar (M2M) 6 months after surgery were recorded. Results: There was no statistically significant difference in the postoperative bleeding, infection, pain, and distal periodontal probing depth of M2M between two groups (P>0.05). The swelling and opening limitation in the experimental group were less than those in the control group (P<0.05). The incidence of delayed-onset infection in the experimental group (2.8%) was lower than that in the control group (11.2%), and the difference between the two groups was statistically significant (P<0.05). Conclusion: Gingival flap secondary closure could alleviate BeM3M postoperative complications, reduce the incidence of delayed-onset infection, and had no adverse effect on distal periodontal probing depth of M2M. References | Related Articles | Metrics

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Retrospective Study of 13 Cases of Soft Tissue Defects after Oral Cancer Resection Repaired with Superficial Branch of Superficial Circumflex Iliac Artery Flap CHEN Xin, SUN Yawei, HAN Shengwei, LIANG Yi, PU Yumei, HUANG Haohao, SUN Guowen 2025, 41(8): 685-689.  DOI: 10.13701/j.cnki.kqyxyj.2025.08.008 Abstract ( 74 )   PDF (2616KB) ( 40 )   Objective: To explore the clinical application value of the superficial branch of superficial circumflex iliac artery (SCIA) flap by reviewing the clinical data of 13 patients with oral cancer. Methods: In 13 patients, the superficial branch of the SCIA flap, which only supplied and dissected the superficial branch of the SCIA, was used to reconstruct the defect after radical surgery of oral cancer. Patients were followed up for 3-6 months to complete the evaluation of the repair effect. Results: The superficial branch of the SCIA was found in all 13 patients. In each patient, the superficial branch of the SCIA flap was successfully prepared by only dissecting the superficial branch of the SCIA. The average area of the dissected flaps was (38.00±8.48) cm2, and the average length of the pedicle was (6.70±0.71) cm. Twelve patients had successful outcome with satisfactory form of the flap and good recovery of functions such as phonetic and eating functions. One patient failed due to vascular thrombosis and was replaced with left radial forearm free flap. Then, the skin paddle of the superficial branch of the SCIA flap was fixed into a full-thickness skin graft to repair the defect in the forearm area. The wounds in the iliac region were directly sutured and achieved primary healing with a hidden scar in all patients. Conclusion: The superficial branch of the SCIA flap has a simple preparation process and can meet the general requirements for the reconstruction of soft tissue defects after oral cancer radical surgery. The flap only leaves a hidden scar in the iliac region and has low donor site morbidity. It is worthy of clinical popularization. References | Related Articles | Metrics

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Clinical Retrospective Study on 14 Cases of Secretory Carcinoma of Salivary Gland WANG Xiqian, LI Juqiang, PENG Liwei 2025, 41(8): 690-694.  DOI: 10.13701/j.cnki.kqyxyj.2025.08.009 Abstract ( 118 )   PDF (2484KB) ( 38 )   Objective: To discuss the clinical manifestations, imaging features, pathological features, differential diagnoses, treatment methods, and prognosis of secretory carcinoma of salivary gland (SCSG). Methods: A total of 14 SCSG patients admitted to the Department of Oral and Maxillofacial Surgery, Henan Provincial People’s Hospital from February 2018 to August 2024 were enrolled. Clinical data were retrospectively analyzed, and a comprehensive analysis and discussion were carried out. Results: Fourteen patients were included (12 males and 2 females), aged 15-64 years (mean age 48.4 years). The disease duration ranged from 2 months to 26 years. Tumor locations included the parotid gland (10 cases), submandibular gland (1 case), hard palate (1 case), and lip (2 cases). Tumor diameters ranged from 1.5 to 7.8 cm. All patients underwent surgical resection. Immunohistochemical analysis revealed strong diffuse positivity for Cytokeratin 7 (CK7), S-100 protein (S-100), and GATA binding protein 3 (GATA3) in all cases. The Ki67 proliferation index ranged from 5% to 30%, and Ets variant 6 (ETV6) rearrangements were detected in 6 cases. Lymph node metastasis was observed in 2 cases (14.3%). Postoperative interventions included radiotherapy/chemotherapy (1 case), radiotherapy alone (1 case), and radioactive particle implantation (3 cases). During follow-up until December 2024, recurrence was observed in 1 case. Conclusion: SCSG is a rare low-grade malignant salivary gland tumor with a favorable prognosis. The clinical manifestations and imaging features are not specific. Diagnosis mainly depends on characteristic histopathology, immunohistochemistry, and molecular detection. Prophylactic cervical lymph node dissection is unnecessary in the absence of confirmed metastasis. Targeted therapy against ETV6 rearrangements may represent a novel therapeutic avenue. References | Related Articles | Metrics

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Three-Dimensional Alveolar Bone Resorption Assessment and Periodontitis Staging Based on Deep Learning QIU Yue, HAN Yangping, DENG Guanghong, LI Jing 2025, 41(8): 695-699.  DOI: 10.13701/j.cnki.kqyxyj.2025.08.010 Abstract ( 141 )   PDF (1650KB) ( 79 )   Objective: To develop a multi-stage deep learning-based model for automatic quantitative assessment of three-dimensional alveolar bone resorption, providing intelligent quantitative indicators for periodontitis staging. Methods: Cone beam computed tomography (CBCT) scans from 100 periodontitis patients were collected. A multi-task segmentation strategy combining fully Convolutional Neural Network for volumetric medical image segmentation (V-Net) and transformer-based encoder-decoder network for efficient and accurate 3D medical image (UNETR++) was proposed to achieve high-precision segmentation of teeth, alveolar bone, and the cemento-enamel junction (CEJ). By combining dilation operations and contact-area ratio calculations, complemented by clustering in the CEJ direction, the three-dimensional alveolar bone resorption was quantitatively measured. Preliminary determination of periodontitis staging was acquired based on the 2018 new classification of periodontal diseases. Results: The model automatically segmented the teeth, alveolar bone, and CEJ, achieving Dice similarity coefficient (DSC) of 95.7%, 91.5%, and 87.9%. The model also demonstrated high accuracy and stability in terms of average surface distance (ASD), hausdorff distance (HD), and sensitivity (SEN). The model enabled multidimensional analysis of bone resorption in the mesiodistal and buccolingual directions. Compared with periodontists’ evaluations, the overall accuracy of periodontitis staging by this model was 85%, with a high level of agreement (Kappa=0.773). The model achieved an F1 score of 1.00 in identifying severe alveolar bone resorption (Stage Ⅲ or Ⅳ). A paired t-test (P<0.01) indicated a significant improvement in efficiency over manual assessment. Conclusion: This method can measure three-dimensional alveolar bone resorption quickly and accurately, providing a valuable reference for precise periodontitis staging and clinical diagnosis. References | Related Articles | Metrics

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Role and Mechanism of Paeoniflorin Promoting β-Defensin Expression in Candidal Stomatitis XIAO Lijun, PAN Yan, YANG Jiantang 2025, 41(8): 700-706.  DOI: 10.13701/j.cnki.kqyxyj.2025.08.011 Abstract ( 89 )   PDF (3174KB) ( 60 )   Objective: To study the role and mechanism of paeoniflorin (PF) promoting β-defensin expression in candidal stomatitis. Methods: The model of candida albicans (C.a) infected Leuk-1 cells to detect the antibacterial ability of β-defensin was established. Quantitative reverse transcription polymerase chain reaction (RT-qPCR) and enzyme-linked immunosorbentAssays (ELISA) were used to detect the gene and protein expression level of β-defensin (HBD-1, HBD- 2, HBD-3). The expressions of phosphorylated P65 in NF-κB signaling pathway were detected by Western blot. Results: CCK-8 results showed that PF at the concentration of 5 μmol/L and 10 μmol/L was selected to treat Leuk-1 cells for 24 h for subsequent experiments which could significantly inhibit the adhesion rate of C.a to Leuk-1 (P<0.05). RT-qPCR and ELISA results showed that 5 μmol/L and 10 μmol/L concentrations of PF could induce Leuk-1 to express HBD-1, -2, and -3, which were statistically significant compared with the blank control group (P<0.01), and the survival rate of C.a under the action of PF decreased significantly. The expression of p-P65 protein was increased by PF. Under the action of inhibitors, the expression of HBD-1, -2, and -3 genes and proteins decreased significantly, the survival rate of C.a increased significantly (P<0.0001). Conclusion: PF induces Leuk-1 cells to secrete and express β-defensins and mucoprotein 1 mainly via P65-NF-κB signal pathway, which could inhibit the growth and control the infection and invasion of C.a, which provided a basis for PF to prevent and treat candida stomatitis and other oral mucosal disease. References | Related Articles | Metrics

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Analysis on Incidence Risk and Risk Factors of Oral Mucositis in 215 Oral Cancer Patients Receiving Postoperative Adjuvant Chemotherapy WANG Kegang, ZHANG Wenjing 2025, 41(8): 707-714.  DOI: 10.13701/j.cnki.kqyxyj.2025.08.012 Abstract ( 102 )   PDF (1007KB) ( 48 )   Objective: To analyze the risk and risk factors of oral mucositis (OM) in 215 oral cancer patients who received postoperative adjuvant chemotherapy. Methods: A total of 215 oral cancer patients who received postoperative adjuvant chemotherapy and treated in the Department of Stomatology of our hospital from January 2020 to January 2023 were selected as the research subjects. According to whether OM occurred after the end of chemotherapy, they were divided into the OM occurrence group and the non-OM occurrence group. The clinical data of the two groups of patients were collected and compared. The influencing factors related to the occurrence of OM in patients were screened, and a nomogram prediction model was drawn. The calibration curve and the receiver operating characteristic curve (ROC) were plotted to evaluate the accuracy and effectiveness of the nomogram model in predicting OM in oral cancer patients receiving postoperative adjuvant chemotherapy. Results: Among the enrolled patients, there were 131 males and 84 females, with an age range of 52 to 77 years, and an average age of (64.57±7.04) years. OM occurred in 89 patients, with an incidence rate of 41.4%. Univariate analysis and logistic regression analysis screened out a history of alcohol consumption (OR=12.302, 95%CI: 1.836-82.441), the long diameter of the tumor (OR=2.092, 95%CI: 1.221-3.584), the operation time (OR=1.018, 95%CI: 1.005-1.031), the intraoperative blood loss (OR=1.012, 95%CI: 1.002-1.022), the fluorouracil-containing regimen (OR=6.450, 95%CI: 1.266-32.858), 6 cycles of chemotherapy (OR=1.056, 95%CI: 1.002-1.112), and serum interleukin-6 (IL-6) before chemotherapy (OR=1.143, 95%CI: 1.074-1.217) as independent risk factors for the occurrence of OM in oral cancer patients receiving postoperative adjuvant chemotherapy. Serum albumin (ALB) (OR=0.922, 95%CI: 0.865-0.983) and pre-albumin (PA) (OR=0.985, 95%CI: 0.973-0.997) before chemotherapy were independent protective factors for the occurrence of OM in oral cancer patients receiving postoperative adjuvant chemotherapy. The calibration curve showed that the nomogram model had a high goodness of fit (χ2=4.999, P=0.758). The ROC analysis demonstrated an area under the curve (AUC) of this model in predicting the occurrence of OM in oral cancer patients receiving postoperative adjuvant chemotherapy was 0.832 (95%CI:0.777-0.887), which was significantly higher than the independent prediction effectiveness of each factor. Conclusion: A history of alcohol consumption, tumor long diameter, operation time, intraoperative blood loss, chemotherapy regimen and duration, as well as serum ALB, PA, and IL-6 before chemotherapy are influencing factors for the occurrence of OM in oral cancer patients receiving postoperative adjuvant chemotherapy. References | Related Articles | Metrics

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Minimally Invasive Treatment of Calcified Root Canal in Discolored Anterior Tooth Using Digital Guide Plate Combined with Intracoronal Bleaching: A Case Report CHENG Mingyue, MIAO Leiying, MENG Jiali, TANG Xuna, REN Shuangshuang 2025, 41(8): 715-718.  DOI: 10.13701/j.cnki.kqyxyj.2025.08.013 Abstract ( 99 )   PDF (5094KB) ( 57 )   With the development of the concept of minimally invasive dental treatment, the management of calcified root canals in traumatised teeth and the improvement of aesthetic results should follow the principle of preserving the maximum amount of dental tissue. This article reported a case of minimally invasive treatment of a calcified root canal in a discoloured anterior tooth using digital guide combined with intracoronal bleaching technique. References | Related Articles | Metrics

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Klebsiella Pneumoniae Infection in Maxillofacial Multiple Spaces of Children with Diabetes: A Case Report SUI Fuyong, XU Bingning, DU Yue, YE Zheng, ZHANG Fuyin 2025, 41(8): 719-722.  DOI: 10.13701/j.cnki.kqyxyj.2025.08.014 Abstract ( 76 )   PDF (3185KB) ( 317 )   Klebsiella pneumoniae, a Gram negative bacterium, is an important pathogen in respiratory tract infections and often causes severe pneumonia. However, cases of multi sites infections in the maxillofacial region are relatively rare. This paper reports a child with diabetes diagnosed as maxillofacial multi space infection, and the bacteria culture showed Klebsiella pneumonia infection. References | Related Articles | Metrics

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Application of "Bone Lid Technique" with Piezosurgery in Extraction of Left Impacted Mandibular Supernumerary Tooth with Cyst: A Case Report GUO Meiling, XU Wei, WANG Yujiang 2025, 41(8): 723-726.  DOI: 10.13701/j.cnki.kqyxyj.2025.08.015 Abstract ( 110 )   PDF (4156KB) ( 154 )   Supernumerary teeth are common clinical anomalies in the number of teeth, which can occur in any position of the jaw. Impacted supernumerary teeth can lead to displacement of neighboring teeth, root resorption, and cysts in jaw, which often need to be extracted. The traditional method of extracting impacted supernumerary teeth requires a large amount of bone removal, resulting in a large amount of bone tissue loss and surgical trauma. In this paper, we report the extraction of an impacted supernumerary tooth with cyst in left mandible by "bone lid technique" through piezosurgery. References | Related Articles | Metrics

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Modified Periodontally Accelerated Osteogenic Orthodontics (PAOO) in Treatment of Skeletal Class Ⅱ Malocclusion: A Case Report ZENG Yu, WANG Xiaoxuan, ZHANG Maoqi, ZHANG Aijuan, GAO Ya, XIONG Hui, CAO Zhengguo 2025, 41(8): 727-732.  DOI: 10.13701/j.cnki.kqyxyj.2025.08.016 Abstract ( 117 )   PDF (5715KB) ( 103 )   This article reports a clinical case of skeletal Class Ⅱ malocclusion treated with modified periodontally accelerated osteogenic orthodontics (PAOO). During the presurgical orthodontic decompensation phase, the modified PAOO technique was performed, featuring a papilla-preserving incision design, full-thickness flap elevation, piezocision-assisted interradicular corticotomy, bone augmentation without collagen barrier membrane (using bone graft material alone), and an innovative suturing method. A 24-month follow-up demonstrated significant increases in labial bone plate thickness and keratinized gingiva width at the surgical site, with stable long-term outcomes and no notable gingival recession or severe periodontal inflammatory reactions. The modified protocol effectively reduced surgical trauma and complication risks while ensuring therapeutic efficacy. References | Related Articles | Metrics