Research Progress on Resolvin D1 in Field of Bone Defect Repair

doi:10.13701/j.cnki.kqyxyj.2026.08.001

Abstract

Abstract: Bone defects resulting from trauma, infection, or congenital factors present significant challenges in clinical treatment, as their repair involves complex inflammatory and regenerative regulation. Specialized proresolving mediators (SPMs) are a class of endogenous lipid mediators that actively promote inflammation resolution and tissue repair. Resolvin D1 (RvD1), an SPM derived from omega-3 polyunsaturated fatty acids, plays a crucial role in regulating inflammatory responses and promoting tissue regeneration. This review focuses on the biological characteristics and mechanisms of RvD1, its application in the repair of oral and maxillofacial bone defects, and its prospects and challenges, aiming to provide new insights for optimizing bone repair therapeutic strategies.

Key words: resolvin D1, bone regeneration, bone defect, bone tissue repair

LINGHU Changfeng, TANG Zhenglong. Research Progress on Resolvin D1 in Field of Bone Defect Repair[J]. Journal of Oral Science Research, 2026, 42(8): 639-643.

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