Effect of Guided Bone Regeneration on Inflammatory Susceptibility of Peri-implant Soft Tissue

doi:10.13701/j.cnki.kqyxyj.2023.08.010

Abstract

Abstract: Objective: To evaluate the effect of guided bone regeneration (GBR) on the long-term stability and inflammatory susceptibility of soft tissues around the implants. Methods: A total of 62 soft tissue level implants with keratinized gingival width ≥2 mm were selected for 12-24 months. After horizontal GBR (absorbable collagen membrane combined with 1∶1 autogenous bone and xenogenous bone replacement materials), 12 patients with 27 implant dentures were implanted and fixed (experimental group). There were 16 patients with the same system of implants in the mandibular posterior area undergoing routine implant operation, with a total of 35 implants (control group). Clinical indexes of implants were examined and the probing depth, modified plaque index, and modified sulcus bleeding index were recorded. Gingival crevicular fluid around all implants and a healthy control natural tooth were collected using the same filter strip. ELISA was used to detect the content of IL-1β, IL-6, TNF-α, MMP-8 . Results: The survival rates of both groups after 12-24 months of loading were 100%. After an average load of (18.70±4.45) months, PD of the experimental group was lower than that of the control group (P<0.05), while there was no significant difference in mSBI and mPLI between two groups (P>0.05). There were no significant differences in the contents of various cytokines between two groups and between the implants and healthy natural teeth (P>0.05). Conclusion: GBR with 1∶1 autogenous bone/xenograft had no significant effect on the stability and inflammatory susceptibility of the soft tissue around the implant.

Key words: mandibular posterior region, guided bone regeneration, 1∶1 autogenous bone/allogeneic bone mixed graft, inflammatory factor, inflammatory susceptibility

JIANG Zhaoxia, KONG Dejing, LI Yuxuan, LIU Mingli, QU Zhe. Effect of Guided Bone Regeneration on Inflammatory Susceptibility of Peri-implant Soft Tissue[J]. Journal of Oral Science Research, 2023, 39(8): 715-720.

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