Clinical Trial of Guided Tissue Regeneration Membrane in Repairing Alveolar Bone Defect Secondary to Tooth Extraction.

doi:10.13701/j.cnki.kqyxyj.2017.07.023

Abstract

Abstract: Objective: To explore the efficacy and safety of suided tissue regeneration membrane (GTRM) in repairing alveolar bone defect secondary to tooth extraction. Methods: A randomized, open, parallel, positively controlled (Bio-gide) clinical trial was performed. The major index for evaluating efficacy was imaging examination. The secondary indexes for evaluating efficacy were surgical wound healing, rejection reaction, changes of bone metabolism, and bone infection signs. The incidence of adverse reaction was recorded for safety evaluation. Results: Forty cases were included and 39 cases completed the clinical trial. The effective rates of imaging examination in GTRM and Bio-gide group were 89.47% and 95%, respectively. The wound healing time of both groups was less than 12 days. No rejection reaction, bone metabolic change, and bone infection sign were observed. The incidences of adverse events in ADM group and Bio-gide group were 5.00% and 0.00%, respectively. Conclusion: No significant difference was found as to efficacy and safety in repairing bone defect secondary to tooth extraction between GTRM group and Bio-gide group.

Key words: Tooth extraction , Defect of alveolar bone, Guided bone regeneration, Guided tissue regeneration membrane, Clinical trial

CLC Number:

R782.1

LUO Zheng-wen, LIU Ji-yuan, LI Jia, PAN Jian.. Clinical Trial of Guided Tissue Regeneration Membrane in Repairing Alveolar Bone Defect Secondary to Tooth Extraction.[J]. Journal of Oral Science Research, 2017, 33(7): 782-786.

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