HemoglobinA1c in Gingival Crevicular Blood Screening for Diabetes

doi:10.13701/j.cnki.kqyxyj.2017.08.014

Abstract

Abstract: Objective: To determine if hemoglobinA1c (HbA1c) gingival crevicular blood (GCB) could be used to build a predictive model for diabetes. Methods: Patients were divided into two groups based on the history of diabetes and the results of HbAlc in finger-stick blood (FSB). Group 1 was diabetes and Group 2 was without diabetes. FSB and GCB were collected from moderate or severe periodontitis patients with adequate bleeding on probing. Glucose and HbA1c levels were analyzed. The Pearson correlation coefficient was used to measure the correlation between glucose and HbA1c values in FSB and GCB. A receiver operator characteristic (ROC) curve analysis was performed to determine an optimal GCB HbA1c criterion value for a positive diabetes screening. Results: The pearson correlation coefficients were 0.993 and 0.926 for FSB and GCB glucose, respectively, and were 0.977 and 0.829 for FSB and GCB HbA1c. The ROC analysis identified a criterion value of 5.7% for the GCB HbA1c test with high sensitivity (100%) and high specificity (95.2%), corresponding to FSB HbA1c values ≥ 6.5% (in the diabetes range). Conclusion: HbA1c in GCB samples may be an acceptable predictor for diabetes screening.

Key words: Periodontitis , Diabetes , Gingival crevicular blood , HbAlc

CLC Number:

781.4

WU Juan, ZHAO Jie, ZHANG Xuan, SUN Wei-bin, LIN Yue, LIN Liang-yuan. HemoglobinA1c in Gingival Crevicular Blood Screening for Diabetes[J]. Journal of Oral Science Research, 2017, 33(8): 856-859.

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