Screening of Key MiRNAs during Salivary Gland Development in Mice and Functional Prediction.

doi:10.13701/j.cnki.kqyxyj.2017.08.013

Abstract

Abstract: Objective: To screen differential expression of miRNAs during salivary gland development in mice. Methods: Using microarrays, miRNA expression profiles were established at selected time points during development (E18.5, E19.5, P0, P3) of the murine submandibular gland. Furthermore, using GENESPRING10.0, Quantile normalization was established. According to Gene Ontology, the functions were predicted. Results: The expressive profiles of miRNA were established. The miRNAs whose expressive signal strength changed greatly were mmu-miR-133a, mmu-miR-721, mmu-miR-1, mmu-miR-133b, mmu-miR-133a, and mmu-miR-206. Conclusion: The miRNAs whose expressive signal strength changed greatly may play an important role in the salivary gland development.

Key words: MicroRNA , Submandibular gland , Microarray

CLC Number:

R782.7

CUI Li-juan, LIU Guo-qin.. Screening of Key MiRNAs during Salivary Gland Development in Mice and Functional Prediction.[J]. Journal of Oral Science Research, 2017, 33(8): 852-855.

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