Experimental Study on Repair of Critical-size Calvarial Defects in Osteoporotic Rats by Biphasic Calcium Phosphate Ceramic Scaffold

doi:10.13701/j.cnki.kqyxyj.2019.04.017

Abstract

Abstract: Objective: To study the effect of the biphasic calcium phosphate ceramic scaffold (BCP) on the repair of critical-size calvarial defects in SD rats with osteoporosis. Methods: SD rats were made into critical-size calvarial defects with osteoporosis. BCP was used to repair the defect of the skull. The rats were divided into four groups, i.e. the Ctrl group, the OP group, the Ctrl+BCP group, and the OP+BCP group. Rats in each group were sacrificed 8 weeks later and the differences in bone formation were detected by imaging findings (Micro-CT) and histological manifestations (Masson staining and hematoxylin-eosin staining). Results: No obvious new bone was found in the Ctrl group and the OP group. New bone can be found in the Ctrl+BCP group and the OP+BCP group, and the new bone in the OP+BCP group was significantly less than that in the non-osteoporosis group (the Ctrl+BCP group). Conclusion: BCP can be used as the scaffold for the repair of critical-size calvarial defects in SD rats with osteoporosis, but the repair effect is weaker than that of normal SD rats.

Key words: Calcium phosphate biphasic (BCP), Osteoporosis, Critical-size calvarial defects, Bone regeneration

PENG Shuang-lin, YAO Zhi-hao, LUO Dao-wen, YANG Shuang-lin, LI Yong, XIAO Jin-gang. Experimental Study on Repair of Critical-size Calvarial Defects in Osteoporotic Rats by Biphasic Calcium Phosphate Ceramic Scaffold[J]. Journal of Oral Science Research, 2019, 35(4): 377-381.

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