Expression of CD146 in Postnatal Human Dental Pulp Stem Cells

doi:10.13701/j.cnki.kqyxyj.2016.02.004

Abstract

Abstract: Objective: To study the expression of CD146 in postnatal human dental pulp stem cells (DPSCs) and during cell differentiation. Methods: DPSCs were cultured in vitro and determined the expression of CD146 through immunofluorescence and fluorescence activated cell sorting (FACS). DPSCs were cultured in the condition of mineralized inducement. During the inducement, CD146 was detected through RT-PCR and immunofluorescence. Results: There was positive expression of CD146 in DPSCs. The results of FACS showed that the positive rate of CD146 was 58.78% in DPSCs. During odontogenetic differentiation, confirmed by DSP, the expression of CD146 was down-regulated. Conclusion: There was relatively specific expression of CD146 in DPSCs. CD146 may be a specific marker of DPSCs.

CLC Number:

R780.1

YANG Xue-chao, LV Xiao-shuai.. Expression of CD146 in Postnatal Human Dental Pulp Stem Cells[J]. Journal of Oral Science Research, 2016, 32(2): 122-125.

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