Effects of PTEN on Proliferation and Apoptosis of Periodontal Ligament Cells Induced by Hydrogen Peroxide.

doi:10.13701/j.cnki.kqyxyj.2017.08.022

Abstract

Abstract: Objective: To investigate the effects of PTEN on proliferation and apoptosis of periodontal ligament cells induced by hydrogen peroxide. Methods: Human periodontal ligament cells were isolated and cultured in vitro, and then transfected with PTEN small interfering RNA or small interfering RNA negative control. After H₂O₂ treatment, PTEN expression was detected in cells by Western blot. Results: PTEN expression was inhibited in human periodontal ligament cells transfected with PTEN small interfering RNA. Conclusion: Interference of PTEN expression could inhibit the apoptosis and the proliferation of human periodontal ligament cells induced by H₂O₂.

Key words: Periodontal ligament cells, Proliferation, Apoptosis , Phosphatase and tensin homolog deleted on chromosome ten, Hydrogen peroxide

CLC Number:

R780.1

ZHAO Yuan, WANG Shu, SHAO Bo, GAO Ying. Effects of PTEN on Proliferation and Apoptosis of Periodontal Ligament Cells Induced by Hydrogen Peroxide.[J]. Journal of Oral Science Research, 2017, 33(8): 889-892.

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