Effect of Gli1 Inhibitor GANT61 on Tooth Development in Vitro

doi:10.13701/j.cnki.kqyxyj.2021.01.006

Journal of Oral Science Research ›› 2021, Vol. 37 ›› Issue (1): 23-27.DOI: 10.13701/j.cnki.kqyxyj.2021.01.006

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Effect of Gli1 Inhibitor GANT61 on Tooth Development in Vitro

ZHANG Shixian¹, LIN Chengquan², XIE Changfu³, CHEN Weihui^2*

1. General and Emergency Department, Fujian Key Laboratory of Oral Diseases & Fujian Provincial Engineering Research Center of Oral Biomaterial & Stomatological Key Lab of Fujian College and University , School and Hospital of Stomatology , Fujian Medical University, Fuzhou 350001,China;
2. Department of Oral and Maxillofacial Surgery, Union Hospital, Fujian Medical University, Fuzhou 350001, China;
3. Department of Implantology Ⅱ, School and Hospital of Stomatology, Fujian Medical University, Fuzhou 350001, China

Received:2020-06-28 Online:2021-01-28 Published:2021-01-22

Abstract

Abstract: Objective: To study the effect of Gli1 inhibitor GANT61 on tooth development in mice. Methods: The mouse molar germ in culture system was observed with stereoscope and histology after being affected by the Gli1 inhibitor GANT61, and the size of the tooth germ was measured. Results: Histological analysis showed that the degree of GANT61 treated group’s development was slower compared with that in the control group. Furthermore, the enamel organ was irregular in shape, and the inner enamel epithelial cells were irregularly arranged. The size of the enamel organ was significantly smaller in the high dose of GANT61 compared with that in the control group. Conclusion: GANT61 can block the development of molar by disturbing the development of enamel organ.

Key words: Gli1, GANT61, tooth development, cell differentiation

ZHANG Shixian, LIN Chengquan, XIE Changfu, CHEN Weihui. Effect of Gli1 Inhibitor GANT61 on Tooth Development in Vitro[J]. Journal of Oral Science Research, 2021, 37(1): 23-27.

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Effect of Gli1 Inhibitor GANT61 on Tooth Development in Vitro

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