Research Progress of Th Cell Related Cytokines in Recurrent Oral Ulcer

doi:10.13701/j.cnki.kqyxyj.2021.05.005

Abstract

Abstract: Recurrent aphthous ulcer (RAU) is one of the most common oral mucosal diseases characterized by recurrent and painful ulcerations on the movable or nonkeratinized oral mucosae. Clinically, three types of RAU, namely minor, major, and herpetiform types, can be identified. RAU more commonly affects labial mucosa, buccal mucosa, and tongue. Previous studies indicate that RAU is a multifactorial T cell-mediated immune-dysregulated disease. CD4⁺T cell subsets are closely related to the pathogenesis and development of RAU, which secrete different cytokines and have different functions. In this paper, the research progress of Th cell related cytokines in RAU is reviewed

Key words: recurrent aphthous ulcer, CD4⁺ T cell subsets, cytokines

GAO Xiaolan, WANG Hanming. Research Progress of Th Cell Related Cytokines in Recurrent Oral Ulcer[J]. Journal of Oral Science Research, 2021, 37(5): 397-400.

References

[1] Namiki T, Hanafusa T, Ueno M, et al. Severe oral ulcers associated with nivolumab treatment [J]. JAMA Dermatology, 2017, 153(2): 235-237.
[2] Gonçalves PS, Mendez DA, Santos PS, et al. The diagnosis and treatment of multiple factitious oral ulcers in a 6-year-old boy [J]. Case Rep Dent, 2017, 2017:1986834.
[3] 毛其芬,上官醉飞.细胞免疫功能及辅助型T细胞因子在口腔扁平苔藓中的作用[J].中国微生态学杂志,2017,29(2)162-165.
[4] Chiang CP, Yu-Fong Chang J, Wang YP, et al. Recurrent aphthous stomatitis-etiology, serum autoantibodies, anemia, hematinic deficiencies and management [J]. J Formos Med Assoc, 2019, 118(9):1279-1289.
[5] 王婷婷,张敬,王兵等.复发性阿弗他溃疡患者外周血中IL-2 和IL-10 水平变化及临床意义[J].现代医药卫生,2013,29(14):2083-2084.
[6] 孙黎飞,刘海军,于广远,等.复发性口腔溃疡患者的细胞免疫功能研究[J].中国免疫学杂志,2001,17(6):332-333.
[7] Bhosale SS, Rajput BS, Takkar H, et al. Establishment of role of IL-2, IL-10 and IL-12 in patients with recurrent aphthous stomatitis-a clinical study [J]. J Contemp Dent Pract, 2018, 19 (10):1242-1245.
[8] 王红灵,刘舒萍.复发性口腔溃疡免疫细胞的效应[J].中国校医,2020,34(7):532-535.
[9] 杜芹,田鲲,廖楚航.复发性阿弗他溃疡Th1/Th2细胞因子的检测[J].成都医学院学报,2013,8(6):657-660.
[10] 陈茜,王冬平,蔡扬,等.复发性阿弗它溃疡患者血清中Th1,Th2类因子表达及意义[J].实用口腔医学杂志,2015,31(6):826-829.
[11] 霍晓,韩宁.半导体激光治疗SD大鼠创伤性口腔溃疡的实验研究[J].口腔医学研究,2020,36(8):770-775.
[12] 贺晓明,王汉明,杨湘晖,等.细胞因子基因多态性与汉族人群及糜烂型口腔扁平苔藓易感性的Meta分析[J].临床口腔医学杂志,2019,35(8):495-501.
[13] 马金昀,徐玲霞,杨月,等.复发性口腔溃疡症状积分与炎性炎症因子的相关性及加味黄连甘草汤的治疗作用[J].上海中医药大学学报,2017, 31(1): 18-23.
[14] Avci E, Akarslan ZZ, Erten H, et al. Oxidative stress and cellular immunity in patients with recurrent aphthous ulcers [J]. Braz J Med Biol Res,2014,47(5):355-360.
[15] Chaudhuri K, Nair KK, Ashok L. Salivary levels of TNF-αin patients with recurrent aphthous stomatitis:a cross-sectional study [J] . J Dent Res Dent Clin Dent Prospects, 2018, 2(1):45-48.
[16] 陈远东,杨海,邱海山,等.复发性口腔溃疡患者血清中TNF-α,IL-2及T淋巴细胞亚群的变化[J].海南医学,2017,28(1):94-95.
[17] Hegde S, Ajila V, Babu S, et al. Evaluation of salivary tumour necrosis factor-alpha in patients with recurrent aphthous stomatitis [J]. Eur Oral Res, 2018, 52(3):157-161.
[18] 彭于治,蔡扬.复发性阿弗他溃疡患者血清中IL-17 和IL-23 的表达[J].贵阳医学院学报,2014,39(1):18-20.
[19] 邹玉红,杨静,陈春华.复发性口腔溃疡患者血清中TNF-α、IL-2,6与免疫功能的相关性[J].海南医学院学报,2015,21(9):1299-1301.
[20] Karakus N, Yigit S, Rustemoglu A, et al. Effects of interleukin (IL) 6 gene polymorphisms on recurrent aphthous stomatitis [J]. Arch Dermatol Res,2014,306(2):173-180.
[21] 谢方英,陈浙丽,高月蓝.益气养阴生肌方对复发性口腔溃疡大鼠的治疗作用及其对黏膜炎症因子和机体免疫功能的影响[J].中国临床药理学与治疗学,2019,24(1):20-26.
[22] 管翠强,郭洪波, 武云霞,等.复发性口腔溃疡患者的氧化应激与细胞免疫状态研究[J].中国药物与临床,2018,18(6):884-885.
[23] 杨林,吕丹.细胞因子对类风湿性关节炎骨平衡的调节作用[J].生命科学,2019,31(1):35-43.
[24] 吴伟,宣璐,李幼华. 复发性口疮溃疡期免疫功能的变化及其意义[J].现代实用医学,2009,21(9):1001-1002.