Application of Chitosan Alginate Composite Sponge for Treatment of Dry Socket in Rats

doi:10.13701/j.cnki.kqyxyj.2021.08.019

Abstract

Abstract: Objective: To study the therapeutic effect of chitosan alginate sponge in dry socket of rats and to provide basis for clinical application. Methods: Chitosan sodium alginate composite sponge was prepared and performed in vitro bacteriostatic test. 45 SD male rats were extracted the maxillary first molar and infected with dry socket, which were randomly divided into three groups: Group A, blank group, Group B, chitosan alginate composite sponge group, and Group C, iodine imitation yarn group. The wound healing was observed and recorded after treatment. The maxillary bone was removed and decalcified. HE staining was used for histopathological observation, and the expression of gingival IL-6 and IL-10 was detected by immunohistochemistry. Results: Compared with Group A, Group B had better healing and inflammation control observed by naked eye, histopathological analysis, and immunohistochemistry analysis (P<0.05), and there was no difference between Group B and Group C (P＞0.05). Conclusion: Chitosan sodium alginate composite sponge has antibacterial and anti-inflammatory property. The treatment of rat dry socket with sponge can achieve the same therapeutic effect as iodine imitation yarn.

Key words: dry socket, chitosan, sodium alginate, composite sponge

CUI Feiyan, LI Lei, LI Na, YUAN Zhuang, MENG Jian. Application of Chitosan Alginate Composite Sponge for Treatment of Dry Socket in Rats[J]. Journal of Oral Science Research, 2021, 37(8): 761-765.

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