Expression and Significance of P53 and Ki67 in Oral Squamous Cell Carcinoma and Relation to the Prognosis of Patients.

doi:10.11839/kqyxzh.2016.01.022

Abstract

Abstract: Objective: To investigate the expression of p53 and ki67 proteins, and their relations to prognosis of patients in oral squamous cell carcinoma (OSCC). Methods: A retrospective study including 132 patients with OSCC was performed, and the follow-up time was at least 5 years. The expression levels of p53 and ki67 were detected by immunohistochemistry and analyzed for the correlation with pathological features and prognosis of patients in OSCC. Results: The expression levels of p53 and ki67 correlated with cell differentiation, TNM stages and tumor site in OSCC (P＜0.05). In addition, the expression of p53 was an independent prognostic parameter in patients with OSCC (P＜0.05), but ki67 expression was not. Conclusion: The expression level of p53 is an effective biomarker and an independent prognostic parameter in oral squamous cell carcinoma

CLC Number:

R739.8

Palati·Tuerxun, Reziya·Aini, Muhetaer·Huojia.. Expression and Significance of P53 and Ki67 in Oral Squamous Cell Carcinoma and Relation to the Prognosis of Patients.[J]. Journal of Oral Science Research, 2016, 32(1): 87-90.

References

[1] Liao CT, Huang SF, Chen IH, et al. Outcome analysis of patients with pn2 oral cavity cancer [J]. Ann Surg Oncol, 2010, 1∶1118-26
[2] Leandro Luongo de Matos, MD, PhD, Gabriel Manfro, MD, PhD, Ricardo Vieira dos Santos, MD. Tumor thickness as a predictive factor of lymph node metastasis and disease recurrence in T1N0 and T2N0 squamous cell carcinoma of the oral tongue [J]. Oral Maxillofac Pathol,2014,118(2)∶209-217
[3] Sanbao TANG , Dongxuan XU , Bin ZHOU, et al. Analysis of P53 Mutation and Invasion Front Grading in Oral Squamous Cell Carcinomas [J]. Huazhong Univ Sci Technol Med Sci, 2010,30(4)∶525-529
[4] Alexander Grbe, Henning Hanken, Ahmed Al-Dam, et al. P53 immunohistochemical expression does not correlate with clinical features in 207 carcinomas of the oral cavity and in the head and neck region [J]. Clin Oral Invest, 2014, 18∶211-217
[5] 林耿冰,贾静,林李嵩,等.口腔鳞癌中survin、cyclinD1和P53基因的表达及其相关性[J].细胞与分子免疫学杂志,2009,25(12)∶1194-1198
[6] Hsieh JS, Lin SR, Chang MY, et al. APC,K-ras, and p53 gene mutations in colorectal cancer patients:Correlation to alinicopathologic features and postoperative surveillance [J]. Am Surg,2005,71(4)∶336-343
[7] Tommaso Cutilli, Pietro Leocata, Vincenza Dolo, et al. Evaluation of p53 protein as a prognostic factor for oral cancer surgery [J]. British Journal of Oral and Maxillofacial Surgery,2013,51∶922-927
[8] PeiDS, QianGW, TianH, et al. Analysis of human ki-67 gene promoter and identification of the sp1 binding sites for ki-67 transcription [J]. Tumour Biol,2012,33(1)∶257-266
[9] 高志彪,冯正虎,杨兰,等.舌癌不同浸润方式Ki67表达的组织学研究[J].口腔医学研究,2012,28(4)∶331-333
[10] 玉宇,陆洪芬,吴毅,等.Facsin和Ki67在口腔鳞癌中的表达及其临床意义[J].中国癌症杂志,2009,19(4)∶257-261
[11] Cludia Malheiros Coutinho-Camillo,Silvia Vanessa Loureno,Inês Nobuko Nishimoto,et al. Nucleophosmin,p53 and Ki-67 expression patterns on an oral squamous cell carcinoma tissue microarray [J]. Human Pathology,2010,41∶1079-1086
[12] Myoung H, Kim MJ, Lee JH, et al. Correlation of proliferative markers (Ki-67 and PCNA) with survival and lymph node metastasis in oral squamous cell carcinoma: a clinical and histopathological analysis of 113 patients [J]. Oral Maxillofac Surg, 2006, 35∶1005-1010
[13] Gonzalez-Moles MA, Ruiz-Avila I, Gil-Montoya JA, et al. Analysis of Ki-67 expression in oral squamous cell carcinoma: Why Ki-67 is not a prognostic indicator [J]. Oral Oncology,2010,46∶525-530

[1]	. [J]. Journal of Oral Science Research, 2018, 34(2): 107-111.
[2]	ZOU Hai-xiao, YANG Hai-li, ZHAO Yi-fang, SONG Li. Effect and Mechanism of Propranolol on Proliferation, Migration, and Angiogenesis of Human Melanoma A375 cells [J]. Journal of Oral Science Research, 2018, 34(2): 139-143.
[3]	QIN Shuai-hua,LI Xin-ming,LI Wen-lu. Analysis of Influencing Factors of Life Quality of Patients with Oral Cancer after Reconstruction [J]. Journal of Oral Science Research, 2018, 34(2): 144-147.
[4]	DENG Xuan, YANG Fang. Influence of MUC1-siRNA on Migration, Invasion, and PI3K-Akt Signaling Pathway of Human Tongue Cancer Tca Cells [J]. Journal of Oral Science Research, 2018, 34(2): 148-151.
[5]	ZHANG Hou-hua, FAN Hua-li. Effect of Calpain 1 Gene Silencing by RNA Interference on Proliferation and Migration of Oral Squamous Cell Carcinoma Cell Lines HSC3 [J]. Journal of Oral Science Research, 2018, 34(2): 152-156.
[6]	WANG Li, LI Jian-guo. Sedative Effects of Dexmedetomidine for Patients Retained with Tracheal Intubation after Repair of Forearm Flap in Oral Cancer [J]. Journal of Oral Science Research, 2018, 34(2): 157-160.
[7]	LIU Yu-lan, MENG Lin, TANG Qi, BU Wen-huan, HUANG Guo-shuai, DAI Yi-bin, LIU Qi-lin, SUN Hong-chen. Ascorbic Acid Carbon Dots Kill Tongue Squamous Cell Carcinoma Cell by Promoting Autophagy [J]. Journal of Oral Science Research, 2018, 34(1): 35-38.
[8]	ZHOU Xiong-ming, NA Si-jia, PAN Shu-ting, QIU Jia-xuan. Effect of Plumbaginon on Invasion and Migration of Tongue Squamous Cell Carcinoma Cells and Its Mechanism [J]. Journal of Oral Science Research, 2018, 34(1): 39-43.
[9]	ZENG Guang,WEI Ke-wen.. Effect of MAP4K3-mTOR Signaling in Licochalcone A-induced Autophagy and Apoptosis of Human Oral Squamous Cell Carcinoma Cells. [J]. Journal of Oral Science Research, 2017, 33(12): 1241-1245.
[10]	XU Xiao-fang, JIA Xiao-wei, LIANG Li-zhong.. Expression of miR-30d in Tongue Squamous Cell Carcinoma and Effect of Antisense miR-30d on Cell Proliferation and Invasion. [J]. Journal of Oral Science Research, 2017, 33(12): 1262-1265.
[11]	ZHANG Hong-chao, LIU Yun-qing, SHAO Ming-jing, WANG Cui-ping, BI Liang-jia, MENG Pei-song.. Preliminary Study on Therapeutic Effect of AE-PDT on Tongue Squamous Cell Carcinoma in Nude Mice. [J]. Journal of Oral Science Research, 2017, 33(12): 1266-1269.
[12]	TANG Cai-jin, ZENG Qi-xin, FAGN Mei-fei, MA Fei, TAO Ren-Chuan, Niyukty Arjal. Curative Effect of Endogenous Resolvin D1 on Periodontitis in Rats [J]. Journal of Oral Science Research, 2017, 33(12): 1270-1273.
[13]	WU Chang-jing, WANG Wei-Lu, ZHEN En-ming, SHAO Jun.. Effect of YAP1 Small Interfering RNA on Biological Characteristics of Tongue Squamous Cell. [J]. Journal of Oral Science Research, 2017, 33(12): 1278-1281.
[14]	WU Li-bo, PAN Shu-ting, QIU Jia-xuan.. Expression Level and Clinical Efficacy of Multidrug Resistant Proteins before and after Neoadjuvant Chemotherapy in OSCC. [J]. Journal of Oral Science Research, 2017, 33(12): 1298-1301.
[15]	WANG Li-ping, GUO Xue-qi, YAN Yong-yong, ZHA Jun, CHEN Wei-hong, WEI Yong-xiang, ZHU Xin-xin, GUAN Hong-bing, GE Lin-hu. Effect and Functioanl Role of miR-146a in Oral Squamous Cell Carcinoma Tissues and Cell Lines [J]. Journal of Oral Science Research, 2017, 33(11): 1204-1208.