Abstract: Objective: To compare the features of temporomandibular disorders (TMD) between the elderly and college students of Cantonese. Methods: A total of 368 elderlies and 681 college students were included in this study. Subjects with positive symptoms were chosen as experimental group, while the others without any symptoms as control group. The factors were analyzed by unconditional Logistic regression and Chi-square test. Results: In the elderly group, the incidence of TMD was 64.9%. Pain, mandibular movement impairment and joint noises in diminishing order were the three leading common symptoms. In the college group, 42.0% of the students were found with positive symptoms. Joint noises, mandibular movement impairment, pain in diminishing order were the three leading common symptoms. Male and female showed significant differences. The unconditional Logistic regression showed that the loss of posterior teeth, unbalanced chewing and occlusal trauma were the major influencing factors in the elderly group. Meanwhile, the non-conditional Logistic regression showed that psychological factors, occlusal disorders/impaction of mandibular third molar, unbalanced chewing were the major influencing factors in the college student group. Conclusion: The incidence of TMD in the elderly was higher than that of college students in Guangdong. The leading etiological factor and the most common symptom of TMD for the elderly were different from those of college students.