Effect of Progressive Loading on Peri-implant Osseointegration

doi:10.13701/j.cnki.kqyxyj.2025.02.011

Abstract

Abstract: Objective: To investigate the effect of progressive loading on implant osseointegration and marginal bone levels through animal experiment. Methods: Six male beagle dogs were selected, with three implants placed on each side of the mandibles and randomly allocated to immediate loading, progressive loading, and non-loading groups. The non-loading and immediate-loading groups used 2.5 mm and 7.0 mm healing abutments after implant surgery, respectively, and did not change the abutment height during the experiment. The progressive-loading group used a 2.5 mm abutment after implant surgery and loaded the implants by changing the height of the implant-healing abutment (3.5 mm, 5.5 mm, and 7.0 mm) at 2, 4, and 6 weeks after implant placement. The marginal bone levels peri-implant at 0, 4, 6, and 8 weeks following surgery were measured. At eight weeks, bone specimens were obtained for measurements of bone volume/total volume (BV/TV), bone surface/bone volume (BS/BV), trabecular thickness (Tb. Th), trabecular number (Tb. N), trabecular separation (Tb. Sp), and BIC, as well as for Micro-CT analysis and hard tissue sections to look for new bone growth surrounding the implants. Results: A total of 36 implants were inserted, with only one failure in the immediate loading group, resulting in an overall survival rate of 97.2%. Marginal bone levels remained stable, with no significant changes in Micro-CT bone parameters. Active new bone production was seen in hard tissue sections, and the progressive and immediate loading groups' BIC values were significantly greater than those of the non-loaded group. Conclusion: In delayed implantation scenarios, progressive loading post-implantation promotes superior osseointegration compared to non-loading, leading to better bone integration results.

Key words: progressive loading, bone remodeling, bone microstructure analysis, BIC

LI Jiahe, WEI Lingfei, ZENG Ni, LIU Zhonghao. Effect of Progressive Loading on Peri-implant Osseointegration[J]. Journal of Oral Science Research, 2025, 41(2): 147-154.

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