Abstract: Objective: To valuate the survival of CEREC ceramic inlays and onlays with 1-surface and multi-surface after follow up for 8 years. Methods: English databases (Cochrane library, Pubmed, EMbase) and Chinese databases(CBM, VIP, Wan fang ) were searched up to December 31. 2013. Randomized controlled trial and non-randomized trail were collected. The patients with posterior tooth defect were included. We also retrieved special journals, conference proceedings and the references of those studies to avoid omissions. The experiment group was treated with CEREC ceramic inlays or onlays with 1-surface and the control group was CEREC inlays or onlays with multi-surface. Bias risk for individual study was assessed with methods recommended by the Cochrane collaboration and the quality of evidence from this Meta-analysis was assessed with GRADE system. Results: We collected 3 studies totally which included 3538 CEREC ceramic restorations. Results showed that the survival of CEREC ceramic inlays/onlays:2-surface was higher than 1-surface (8 years) (HR=6.32, 95%CI :1.72-23.20, P=0.005); 3-surface was higher than 1-surface (8 years) (HR=5.87, 95%CI :1.84-18.71,P=0.003), and there’s no significant difference between 1-surface and ≥4-surface (HR=1.92, 95%CI :0.42-8.79,P=0.40). Using GRADE system, quality of evidence for 2 outcomes (1-surface vs. 2-surface; 1- surface vs. 3-surface) were low and for 1 outcome (1 surface vs. ≥4surface)was very low. Conclusion: Survival rate(for 8 years) of Cerec ceramic inlays and onlays were reported, the current evidence indicates that the survival rate(for 8 years) do not always increase with the increase of number of surface of inlays or onlays.

Key words: Inlays and onlays , Cerec , Survival , Long-term, HR