Preparation and Characterization of Composite Thermo-sensitive Gel for Alveolar Ridge Preservation.

doi:10.13701/j.cnki.kqyxyj.2017.01.014

Abstract

Abstract: Objective: To develop multi-walled carbon nanotube/nano-hydroxyapatite/chitosan(CS)/β-glycerophosphate(GP) injectable thermo-sensitive gels and to explore its feasibility as alveolar ridge preservation material. Methods: Wet-chemical in-situ precipitation route was used to obtain CNT/HA inorganic composites (HAC), which were dispersed in chitosan solution to obtain multi-walled carbon nanotube/nano-hydroxyapatite/chitosan thermo-sensitive gels. Gelation time, hole size, the porosity, mechanical strength and the percentage weight loss were selected as indicators to optimize the matching. The microstructure and physicochemical properties of the thermo-sensitive gels were characterized. Results: The results showed that the gel-forming property, including certain porosity (84%) and improved mechanical properties (0.441MPa), could be well tuned by controlling the amount of HAC (10 mg/mL) composite incorporated. In addition, certain amounts of HAC made the degradation rate controllable and shorten the clinical operation time to 12 min. Conclusion: The HAC loaded CS/GP composite scaffolds developed in this study exhibited good formability and mechanical properties and it might be a promising selection for bone tissue engineering.

Key words: Alveolar, ridge, preservation, Chitosan, Multi-walled, carbon, nanotubes, Hydroxyapatite
In-situ, precipitation

CLC Number:

R783.1

MU Ting-ting, YANG Tao, ZANG Cheng-cheng, WANG Jian, SUI Lei. Preparation and Characterization of Composite Thermo-sensitive Gel for Alveolar Ridge Preservation.[J]. Journal of Oral Science Research, 2017, 33(1): 60-64.

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