口腔医学研究

口腔医学研究 ›› 2016, Vol. 32 ›› Issue (5): 456-459.DOI: 10.13701/j.cnki.kqyxyj.2016.05.008

• 基础研究论著 • 上一篇    下一篇

颧骨缝牵张成骨的定量研究

张菊会 ,林佳佳 ,张春霞 ,任伟 ,胡红胜 ,邓刚 ,王恩群*   

  1. 安徽医科大学附属安庆医院口腔科 安徽 安庆 246003
  • 收稿日期:2015-07-21 出版日期:2016-05-26 发布日期:2016-05-26
  • 通讯作者: 王恩群,E-mail:2813855002@qq.com
  • 作者简介:张菊会(1974~ ),女,学士,主治医师,安徽人,主要从事口腔科的临床治疗工作。
  • 基金资助:
    安徽省学术和技术带头人专项基金(第六批)

A Rational Study of 3-D External Expansion Appliance for Zygomatic Distraction Osteogenesis.

ZHANG Ju-hui, LIN Jia-jia, ZHANG Chun-xia, REN Wei, HU Hong-sheng, DENG Gang ,WANG En-qun*   

  1. Department of Oral and Maxillofacial Surgery, Anqing Affiliated Hospital, Anhui Medical University, Anqing 246003, China
  • Received:2015-07-21 Online:2016-05-26 Published:2016-05-26

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摘要： 目的:研究缝牵张成骨过程中ALP、BGP 、Ca含量变化与新骨形成的关系。方法:牵张成骨后的标本经过匀浆、离心,进行对硝基苯磷酸盐法测量新形成骨中碱性磷酸酶活性水平,利用骨钙素放射免疫试剂盒测定骨钙素含量,用原子吸收分光光度计测定钙含量。结果:骨中碱性磷酸酶在牵张成骨后1周明显升高,3周达到峰值(3.42±0.35) U/g,5周有所下降,8周时接近对照组水平;骨钙素的水平在牵张成骨后有所增加,3周明显上升,牵张成骨后5周达到峰值(74.86±2.71) ng/g,8周下降接近对照组水平;实验组钙含量明显低于对照组,随牵张成骨进行,钙含量逐渐升高,与对照组比较具有明显统计学意义,牵张成骨后5周,实验组钙含量明显增高,8周时钙含量(46.56±2.20) mg/g接近对照组水平。结论:牵张成骨时大量骨碱性磷酸酶、骨钙素先后形成,牵张区钙化迅速,促进新骨质形成。

关键词: 缝牵张成骨, 碱性磷酸酶, 骨钙素, 钙

Abstract: Objective: To study the connection between the changes of alkaline phosphatase, bone gla protein, calcium and the formation of new bone. Methods: The specimen of sutural expansion osteogenesis (SEO) were ground into flour, centrifugalized, and then the quantitatively measured the level of alkaline phosphate (ALP), bone gla protein (BGP) and calcium (Ca). Results: The ALP level was raised after 1 week, culminated at (3.42±0.35)U/g after 3 weeks and descended obviously after 5 weeks. The BGP level was raised after 3 weeks, culminated at (74.86±2.71)ng/g after 5 weeks and descended obviously after 8 weeks. The Ca content was raised gradually, and closed to the level of control group after 8 weeks. Conclusion: Much ALP and BGP are formed in sequence in the course of SEO, and then the expanded sutures are calcified rapidly, which accelerates the form of new bone.

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