尿源性干细胞及其在口腔医学组织工程中的应用前景

doi:10.13701/j.cnki.kqyxyj.2018.02.024

口腔医学研究 ›› 2018, Vol. 34 ›› Issue (2): 206-208.DOI: 10.13701/j.cnki.kqyxyj.2018.02.024

尿源性干细胞及其在口腔医学组织工程中的应用前景

瞿姣姣^1,2, 王帅^1,2, 吴家媛^2,3*

1. 遵义医学院贵州遵义 563000;
2. 遵义医学院附属口腔医院贵州遵义 563000;
3. 贵州省高等学校口腔疾病研究特色重点实验室贵州遵义 563000;

收稿日期:2016-10-18 出版日期:2018-02-28 发布日期:2018-02-26
通讯作者: 吴家媛,Email:wujiayuan@zmc.edu.cn
作者简介:瞿姣姣(1991~ ),女,四川人,硕士,主要从事牙再生、氟斑牙发病机制研究。
基金资助:
贵州省科学技术基金计划(编号:黔教合基础[2016]1170)
贵州省口腔医学研究生创新基地项目(编号:黔科研合CXJD字(2014) 005)
贵州省高等学校特色重点实验室建设项目(编号:黔教合KY字[2013]109)

Urine-derived Stem Cells and Their Potential Applications in Oral Maxillofacial Tissue Engineering and Regeneration

QU Jiao-jiao^1,2, WANG Shuai^1,2, WU Jia-yuan^2,3*

1. School of Stomatology, Zunyi Medical University, Zunyi 563000, China;
2. Hospital of Stomatology, Zunyi Medical University, Zunyi 563000, China;
3. Guizhou Province Key Laboratory of Oral Diseases Research, Zunyi 563000, China.

Received:2016-10-18 Online:2018-02-28 Published:2018-02-26

摘要/Abstract

摘要： 尿源性干细胞(Urine-derived stem cells,USCs)是存在于尿液中,具有高度增殖性、自我更新能力、多向分化潜能及旁分泌特性的一种成体干细胞。作为一种新型的细胞来源,USCs储备丰富,取材容易,具有极佳的可行性和安全性。USCs利用其多向分化潜能和旁分泌特性参与组织再生的研究,已在临床前动物模型中取得一定成果。其研究成果均展示了USCs在口腔组织工程中的应用潜能。本文就其应用前景作一综述。

关键词: 尿源性干细胞, 组织工程, 牙再生

Abstract: Urine-derived stem cells (USCs) are novel adult stem cells existing in urine which possesses highly expandability, self-renewal capacity, paracrine properties, and multi-differentiation potential. In tissue regeneration, as a new source of cells, the USCs have excellent feasibility and safety. Most importantly, the body has a substantial source of USCs, which can be harvested easily in a non-invasive manner, regardless of the age, sex, and health condition of patients. USCs have been used in preclinical animal models to repair or regenerate tissue, employing either trans-differentiation or paracrine effects to stimulate endogenous cells participating in tissue regeneration. The potential application of USCs in oral maxillofacial tissue regeneration is reviewed in this paper.

Key words: Urine-derived stem cells, Tissue engineering, Tooth regeneration

中图分类号:

瞿姣姣, 王帅, 吴家媛. 尿源性干细胞及其在口腔医学组织工程中的应用前景[J]. 口腔医学研究, 2018, 34(2): 206-208.

QU Jiao-jiao, WANG Shuai, WU Jia-yuan. Urine-derived Stem Cells and Their Potential Applications in Oral Maxillofacial Tissue Engineering and Regeneration[J]. Journal of Oral Science Research, 2018, 34(2): 206-208.

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尿源性干细胞及其在口腔医学组织工程中的应用前景

Urine-derived Stem Cells and Their Potential Applications in Oral Maxillofacial Tissue Engineering and Regeneration

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