口腔医学研究

口腔医学研究 ›› 2018, Vol. 34 ›› Issue (2): 206-208.DOI: 10.13701/j.cnki.kqyxyj.2018.02.024

• 综述 • 上一篇    下一篇

尿源性干细胞及其在口腔医学组织工程中的应用前景

瞿姣姣1,2, 王帅1,2, 吴家媛2,3*   

  1. 1. 遵义医学院 贵州 遵义 563000;
    2. 遵义医学院附属口腔医院 贵州 遵义 563000;
    3. 贵州省高等学校口腔疾病研究特色重点实验室 贵州 遵义 563000;
  • 收稿日期:2016-10-18 出版日期:2018-02-28 发布日期:2018-02-26
  • 通讯作者: 吴家媛,Email:wujiayuan@zmc.edu.cn
  • 作者简介:瞿姣姣(1991~ ),女,四川人,硕士,主要从事牙再生、氟斑牙发病机制研究。
  • 基金资助:
    贵州省科学技术基金计划(编号:黔教合基础[2016]1170)
    贵州省口腔医学研究生创新基地项目(编号:黔科研合CXJD字(2014) 005)
    贵州省高等学校特色重点实验室建设项目(编号:黔教合KY字[2013]109)

Urine-derived Stem Cells and Their Potential Applications in Oral Maxillofacial Tissue Engineering and Regeneration

QU Jiao-jiao1,2, WANG Shuai1,2, WU Jia-yuan2,3*   

  1. 1. School of Stomatology, Zunyi Medical University, Zunyi 563000, China;
    2. Hospital of Stomatology, Zunyi Medical University, Zunyi 563000, China;
    3. Guizhou Province Key Laboratory of Oral Diseases Research, Zunyi 563000, China.
  • Received:2016-10-18 Online:2018-02-28 Published:2018-02-26

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摘要： 尿源性干细胞(Urine-derived stem cells,USCs)是存在于尿液中,具有高度增殖性、自我更新能力、多向分化潜能及旁分泌特性的一种成体干细胞。作为一种新型的细胞来源,USCs储备丰富,取材容易,具有极佳的可行性和安全性。USCs利用其多向分化潜能和旁分泌特性参与组织再生的研究,已在临床前动物模型中取得一定成果。其研究成果均展示了USCs在口腔组织工程中的应用潜能。本文就其应用前景作一综述。

关键词: 尿源性干细胞, 组织工程, 牙再生

Abstract: Urine-derived stem cells (USCs) are novel adult stem cells existing in urine which possesses highly expandability, self-renewal capacity, paracrine properties, and multi-differentiation potential. In tissue regeneration, as a new source of cells, the USCs have excellent feasibility and safety. Most importantly, the body has a substantial source of USCs, which can be harvested easily in a non-invasive manner, regardless of the age, sex, and health condition of patients. USCs have been used in preclinical animal models to repair or regenerate tissue, employing either trans-differentiation or paracrine effects to stimulate endogenous cells participating in tissue regeneration. The potential application of USCs in oral maxillofacial tissue regeneration is reviewed in this paper.

Key words: Urine-derived stem cells, Tissue engineering, Tooth regeneration

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