牙髓源性干细胞在口腔颅颌面组织工程领域的研究进展

doi:10.13701/j.cnki.kqyxyj.2019.03.005

口腔医学研究 ›› 2019, Vol. 35 ›› Issue (3): 218-220.DOI: 10.13701/j.cnki.kqyxyj.2019.03.005

牙髓源性干细胞在口腔颅颌面组织工程领域的研究进展

黄文燕, 葛立宏^*, 曾素娟^*

广州医科大学附属口腔医院广州口腔疾病研究所口腔医学重点实验室广东广州 510140

收稿日期:2018-05-03 出版日期:2019-03-28 发布日期:2019-04-01
通讯作者: * 葛立宏, E-mail:gelh0919@126.com曾素娟, E-mail:13922265473@163.com
作者简介:黄文燕(1992~ ),女,广东茂名人,硕士在读,研究方向为儿童口腔医学。
基金资助:
广州市属高校科研项目(编号:1201610458)

Research Progress of Dental Pulp Derived Stem Cells in Oral Craniofacial Tissue Engineering

HUANG Wen-yan, GE Li-hong^*, ZENG Su-juan^*

Key Laboratory of Oral Medicine, School and Hospital of Stomatology, Guangzhou Medical University, Guangzhou 510140, China.

Received:2018-05-03 Online:2019-03-28 Published:2019-04-01

摘要/Abstract

摘要： 牙髓和根尖乳头等牙髓源性组织中存在间充质干细胞即牙髓源性干细胞,在体外能被成功分离、培养和扩增,并证实具有自我更新、多向分化的潜能,在体内可实现包括牙本质、骨等多种组织的再生。牙髓源性干细胞来源易得,伦理争议低,有望成为组织工程学中最有潜质的种子细胞来源。本文就牙髓源性干细胞的成骨性能、体外成骨系统、在骨组织工程中的部分应用等作一综述。

关键词: 牙髓源性干细胞, 组织工程, 三维支架

Abstract: Recent evidences have shown that a variety of mesenchymal stem cells located in dental pulp-derived tissues such as the dental pulp and apical papilla. It is known that these stem cells have the potential to differentiate into several cell types, including odontoblasts, osteoblasts, and chondrocytes. These stem cells can be isolated and grown under defined tissue culture conditions, and are potential cells for use in tissue engineering, including dental tissues and bone regeneration. This article reviews the osteogenic properties of dental pulp stem cells, osteogenic system in vitro, and their applications in tissue engineering.

Key words: Dental pulp derived stem cells, Tissue engineering, Three-dimensional scaffold

黄文燕, 葛立宏, 曾素娟. 牙髓源性干细胞在口腔颅颌面组织工程领域的研究进展[J]. 口腔医学研究, 2019, 35(3): 218-220.

HUANG Wen-yan, GE Li-hong, ZENG Su-juan. Research Progress of Dental Pulp Derived Stem Cells in Oral Craniofacial Tissue Engineering[J]. Journal of Oral Science Research, 2019, 35(3): 218-220.

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牙髓源性干细胞在口腔颅颌面组织工程领域的研究进展

Research Progress of Dental Pulp Derived Stem Cells in Oral Craniofacial Tissue Engineering

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