辛伐他汀促进骨整合及改善不良成骨条件的研究进展

doi:10.13701/j.cnki.kqyxyj.2019.08.003

摘要/Abstract

摘要： 随着医疗技术的快速发展,人们生活水平的不断提高,种植修复已经成为越来越多牙列缺损患者的首选。一直以来,较差的骨质条件和不良的骨整合是导致种植失败的重要原因,如何促进种植体与周围骨组织的结合,并进一步提升骨质条件较差患者的初期稳定性,成为很多学者研究的热点。大量研究证实辛伐他汀具有促进成骨的作用,对于骨质疏松、牙周炎症和糖尿病等不良条件下的成骨有巨大潜力。本文就辛伐他汀促进种植体骨整合的机制、给药的剂量和方式以及其对不良成骨条件的改善做一综述。

关键词: 辛伐他汀, 骨整合, 骨质疏松, 牙周炎, 糖尿病

Abstract: With the rapid development of medical technology and the continuous improvement of people's living condition, implant restoration is more likely to become the first choice for patients with dentition defects. For a along time, poor bone condition and poor osseointegration are important causes of implant failure. How to promote the integration of implants with surrounding bone tissue and further improve the initial stability of implants in patients with poor bone condition has become a hot issue for many scholars. A large number of studies have confirmed that simvastatin has the effect of promoting osteogenesis. Simvastatin has great potential for osteogenesis under adverse conditions, such as osteoporosis, periodontitis, and diabetes. This article reviews the mechanism of simvastatin in promoting osseointegration of implants, the mode and dosage of administration, and the improvement of poor osteogenesis conditions.

Key words: simvastatin, osteointegration, osteoporosis, periodontitis, diabetes

辛禧瑞, 周延民. 辛伐他汀促进骨整合及改善不良成骨条件的研究进展[J]. 口腔医学研究, 2019, 35(8): 734-737.

XIN Xirui, ZHOU Yanmin. Research Progress of Simvastatin in Promoting Osseointegration and Improving Poor Osteogenic Conditions[J]. Journal of Oral Science Research, 2019, 35(8): 734-737.

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