口腔医学研究

口腔医学研究 ›› 2015, Vol. 31 ›› Issue (1): 64-68.

• 临床研究论著 • 上一篇    下一篇

牙周炎伴糖尿病患者全唾液中Pro-CT含量的检测及其意义

杜军1,何惠宇1*,买买提·牙森2*   

  1. 1. 新疆医科大学第一附属医院口腔修复科 新疆 乌鲁木齐 830000;
    2. 新疆维吾尔自治区卫生厅
  • 收稿日期:2014-06-18 出版日期:2015-01-28 发布日期:2016-04-29
  • 通讯作者: 何惠宇,电话:0991- 4365663
  • 作者简介:杜军(1986~ ),男,河北人,硕士在读,住院医师,主要从事口腔修复学及牙周病学临床及基础的研究。

Detection of Concentration of Pro-CT in Whole Saliva in Patients with Periodontitis Accompanied with Diabetes and its Significance.

DU Jun, HE Hui-yu, Maimaiti Yasen   

  1. Department of Prosthodontics, the First Affiliated Hospital of Xinjiang Medical University, Urumqi 830000
  • Received:2014-06-18 Online:2015-01-28 Published:2016-04-29

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摘要： 目的:比较糖尿病合并牙周炎患者、单纯糖尿病患者、单纯牙周炎患者以及健康者全唾液中降钙素原(Pro-CT)水平,及其与血糖控制情况及牙周病炎严重程度之间的关系。方法:采用病例对照研究,纳入糖尿病合并牙周炎患者(DM+CP组)24例,单纯糖尿病患者(DM组)、单纯牙周炎患者(CP组)以及健康人群各30例,收集受检者静息全唾液,采用酶联免疫吸附试验(ELISA)检测全唾液中Pro-CT水平。结果:DM+CP组全唾液中Pro-CT水平显著高于其他3组,差异极具统计学意义(P<0.01);全唾液中Pro-CT水平随牙周炎严重程度加重而增高,随血糖控制情况的不理想而增高,差异有统计学意义;全唾液中Pro-CT水平与探诊深度(PD)、探诊出血指数(BI)、附着丧失(AL)、缺失牙数均呈正相关,且相关程度由高到低依次为PD、BI、AL、缺失牙数,差异有统计学意义(P<0.05)。结论:糖尿病患者体内的微炎症状态可能与牙周炎症有关,全唾液中Pro-CT水平既受牙周炎症影响也受全身因素的调控。

关键词: 糖尿病, 牙周炎, 全唾液, 炎症因子

Abstract: Objective: To compare the level of procalcitonin (Pro-CT) in whole saliva in diabetic patients with periodontitis, simplex diabetic patients, patients with simplex periodontitis and healthy subjects, and to analyze its relationships with the control on blood glucose and severity of periodontal disease. Methods: By case-control study, there were 24 cases of patients with diabetes accompanied with periodontitis in DM+CP group, 30 cases of simple diabetic patients (DM group), 30 cases of patients with simple periodontitis (CP group) and 30 cases of healthy people. The resting whole saliva of subjects was collected. The level of Pro-CT in whole saliva was detected using enzyme-linked immunosorbent assay (ELISA). Results: The level of Pro-CT in whole saliva in DM+CP group was significantly higher than that in other three groups, and the difference has statistical significance (P<0.01). The level of Pro-CT in whole saliva increased with the increasing severity of periodontitis, increased with not ideal control on blood glucose, and the difference has statistical significance; The level of Pro-CT in whole saliva showed a positive correlation with probing depth (PD), probing bleeding index (BI), attachment loss (AL) and number of missing teeth. Moreover the degrees of correlation from high to low were successively PD, BI, AL and the number of missing teeth. The difference was statistically significant (P<0.05). Conclusion: Micro inflammatory state in patients with diabetes may be associated with periodontal inflammation. The level of Pro-CT in whole saliva was affected by both periodontitis and systemic factors.

Key words: Diabetes Periodontitis , Whole saliva , Inflammatory factor

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