诱导性多能干细胞在牙周组织重建领域的应用进展

doi:10.13701/j.cnki.kqyxyj.2016.08.027

口腔医学研究 ›› 2016, Vol. 32 ›› Issue (8): 883-885.DOI: 10.13701/j.cnki.kqyxyj.2016.08.027

诱导性多能干细胞在牙周组织重建领域的应用进展

陈靓雯,晏奇,施斌^*

武汉大学口腔医学院种植科湖北武汉 430079

收稿日期:2016-03-10 出版日期:2016-08-26 发布日期:2016-08-26
通讯作者: 施斌,E-mail:shibin_dentist@126.com
作者简介:陈靓雯(1991~ ),女,湖北武汉人,硕士在读,主要从事牙周组织重建的相关研究。
基金资助:
国家自然科学基金(编号:H1408)

Application Progress of Induced Pluripotent Stem Cells in the Field of Periodontal Tissue Reconstruction

CHEN Liang-wen, YAN Qi, SHI Bin^*

Department of Implantology, School of Stomatology, Wuhan University. Wuhan 430079, China.

Received:2016-03-10 Online:2016-08-26 Published:2016-08-26

摘要/Abstract

摘要： 把特定的细胞因子负载到病毒上,再导入成熟体细胞,可将已分化的细胞重编程为诱导性多能干细胞(Induced pluripotent stem cells,iPS cells),iPS细胞能够快速增殖同时长期保持未分化状态,并可被诱导形成多种成熟体细胞、组织及器官。可通过组织工程的方法,将iPS细胞与特定细胞因子联合培养,与合适的细胞支架结合,通过细胞的增殖、分化、矿化沉淀,启动成骨及成血管过程,修复缺损的牙周组织。本文对iPS细胞的来源、培养方法,组织工程相关的细胞因子、细胞支架,及iPS细胞在牙周组织重建领域的应用进展作一系统综述。

关键词: 牙周组织重建, 组织工程, iPS细胞, 细胞因子, 细胞支架

Abstract: Through loading specific transcription factors into virus vectors and importing them into mature body cells, somatic cells can be reprogrammed to induced pluripotent stem cells (iPS cells). IPS cells can proliferate and maintain the undifferentiated state, and can differentiate into a variety of mature cells, tissues and organs. By the method of tissue engineering, when culturing iPS stem cells in the medium added with functional cell factors, and combining with the cytoskeleton, the periodontal tissue defects can be reconstructed through cells’ proliferation, differentiation, mineralization precipitation, osteoinduction and vascularization. This article systematically reviews the source, culture methods, tissue engineering-related cytokines, cell bracket, and application of iPS cells in the periodontal tissue regeneration.

Key words: Periodontal tissue regeneration, Tissue engineering iPS stem cells, Cytokines, Cells scaffold

中图分类号:

X703.5

陈靓雯,晏奇,施斌. 诱导性多能干细胞在牙周组织重建领域的应用进展[J]. 口腔医学研究, 2016, 32(8): 883-885.

CHEN Liang-wen, YAN Qi, SHI Bin. Application Progress of Induced Pluripotent Stem Cells in the Field of Periodontal Tissue Reconstruction[J]. Journal of Oral Science Research, 2016, 32(8): 883-885.

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诱导性多能干细胞在牙周组织重建领域的应用进展

Application Progress of Induced Pluripotent Stem Cells in the Field of Periodontal Tissue Reconstruction

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