线粒体动力学在牙周炎中的研究进展

doi:10.13701/j.cnki.kqyxyj.2026.02.002

摘要/Abstract

摘要： 牙周炎是一种常见的口腔慢性感染性疾病,以牙周支持组织的进行性破坏为特征,是成人牙齿缺失的主要原因之一,给个人健康及社会医疗系统带来了沉重负担。研究表明,线粒体动力学是调节细胞内能量代谢、凋亡及免疫反应的关键过程,其失衡所导致的细胞功能障碍是牙周炎发病的重要机制之一。近年来,靶向线粒体动力学已成为改善牙周炎症及骨再生障碍的一种新兴调控策略。本文基于国内外最新研究成果,系统性综述了线粒体动力学的分子机制及其在牙周炎中的研究进展,以及线粒体动力学调控策略在牙周炎治疗中的潜在价值。

关键词: 线粒体动力学, 线粒体融合, 线粒体分裂, 牙周炎

Abstract: Periodontitis is a prevalent chronic infectious oral disease characterized by progressive destruction of periodontal supporting tissues, serving as one of the primary causes of teeth loss in adults and imposing substantial burdens on individual health and healthcare systems. Research indicates that mitochondrial dynamics, a critical process regulating intracellular energy metabolism, apoptosis, and immune responses, plays a significant role in periodontitis pathogenesis through cell dysfunction caused by its imbalance. In recent years, targeting mitochondrial dynamics has emerged as a novel regulatory strategy for ameliorating periodontal inflammation and bone regeneration disorders. Based on the latest domestic and international studies, this review systematically summarizes the molecular mechanisms of mitochondrial dynamics, recent research advancements in periodontitis, and the therapeutic potential of targeting mitochondrial dynamics in periodontitis treatment.

Key words: mitochondrial dynamics, mitochondrial fusion, mitochondrial fission, periodontitis

赵若闻, 吴珺华. 线粒体动力学在牙周炎中的研究进展[J]. 口腔医学研究, 2026, 42(2): 93-98.

ZHAO Ruowen, WU Junhua. Research Progress of Mitochondrial Dynamics in Periodontitis[J]. Journal of Oral Science Research, 2026, 42(2): 93-98.

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