肠道菌群失调与口腔疾病相关性的研究进展

doi:10.13701/j.cnki.kqyxyj.2026.02.003

摘要/Abstract

摘要： 口腔与肠道微生物之间通过口腔-肠道微生物轴形成双向作用环路。肠道菌群失调通过代谢、细菌异位定植、炎症反应与免疫调节等途径影响口腔微生态平衡,与龋病、牙周病、口腔溃疡、口臭、口腔癌等疾病的发生密切相关。本研究旨在阐述肠道菌群与口腔疾病之间的关系及潜在作用机制,期望通过对肠道菌群的调节为口腔疾病的预防和治疗提供参考。

关键词: 口腔-肠道微生物轴, 肠道菌群失调, 口腔疾病, 免疫调节, 代谢产物

Abstract: The oral and gut microbiota form a bidirectional interaction loop through the oral-gut microbial axis. Gut microbiota dysbiosis affects oral microecological balance via pathways such as metabolism, bacterial ectopic colonization, inflammatory responses, and immune regulation, which is closely associated with the occurrence of dental caries, periodontal diseases, oral ulcers, halitosis, oral cancer, and other oral diseases. This study aims to elaborate on the associations between gut microbiota and oral diseases as well as the underlying mechanisms, hoping to provide theoretical references for the prevention, diagnosis, and treatment of oral diseases through modulation of the gut microbiota.

Key words: oral-gut microbiota axis, gut microbiota dysbiosis, dental diseases, immune regulation, metabolites

陈远金, 刘建国. 肠道菌群失调与口腔疾病相关性的研究进展[J]. 口腔医学研究, 2026, 42(2): 99-104.

CHEN Yuanjin, LIU Jianguo. Research Progress on Correlation between Gut Microbiota Dysbiosis and Oral Diseases[J]. Journal of Oral Science Research, 2026, 42(2): 99-104.

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