纳米纤维支架在骨组织工程中的应用

doi:10.13701/j.cnki.kqyxyj.2018.08.002

口腔医学研究 ›› 2018, Vol. 34 ›› Issue (8): 809-811.DOI: 10.13701/j.cnki.kqyxyj.2018.08.002

纳米纤维支架在骨组织工程中的应用

黄山, 刘红^*

吉林大学口腔医院综合治疗科·吉林省牙发育及颌骨重塑与再生重点实验室吉林长春 130021

收稿日期:2017-11-02 出版日期:2018-08-28 发布日期:2018-08-23
通讯作者: 刘红,E-mail:jdliuhong@163.com
作者简介:黄山(1993~ ),女,吉林人,硕士在读,主要从事口腔修复的临床治疗工作。
基金资助:
国家自然科学基金(编号:81771123)

Application of Nanofibrous Scaffold in Bone Tissue Engineering

HUANG Shan, LIU Hong^*

Department of Oral Comprehensive Treatment, Jilin Provincal Key Laboratory of Tooth Development and Bone Remodeling, School and Hospital of Stomatology, Jilin University, Changchun 130021, China

Received:2017-11-02 Online:2018-08-28 Published:2018-08-23

摘要/Abstract

摘要： 纳米纤维支架是具有纳米级别的天然骨分级结构和多孔结构,近年来在骨组织工程中得到广泛应用。骨组织工程由种子细胞、支架和生长因子3个部分组成,其中寻找能够促进细胞长入和引导新骨生长的三维组织工程支架是骨组织工程研究的重点。纳米纤维支架与天然骨细胞外基质形态结构相似,能够促进细胞附着和干细胞分化,所以成为目前促进骨组织再生的理想支架。本文综述了纳米纤维支架制备技术的最新研究进展。

关键词: 骨组织工程, 纳米纤维, 支架, 仿生材料

Abstract: Nanofibrous scaffolds, which are porous and hierarchical, have been widely used in bone tissue engineering in recent years. Bone tissue engineering consists of three parts: suitable seed cells, scaffolds, and growth factors. The research on bone tissue engineering focused on finding three-dimensional tissue engineering scaffolds to promote cell growth and guide bone regeneration. Since nanofibrous scaffolds, which are similar to the extracelluar matrix of natural bone in morphology and structure, can promote cell adhesion and stem cell differentiation, they have become ideal scaffolds in bone regeneration in recent years. In this paper, we review the fabrication technologies of nanofibrous scaffolds and their advanced applications.

Key words: Bone tissue engineering, Nanofiber, Scaffold, Biomimetic material

黄山, 刘红. 纳米纤维支架在骨组织工程中的应用[J]. 口腔医学研究, 2018, 34(8): 809-811.

HUANG Shan, LIU Hong. Application of Nanofibrous Scaffold in Bone Tissue Engineering[J]. Journal of Oral Science Research, 2018, 34(8): 809-811.

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纳米纤维支架在骨组织工程中的应用

Application of Nanofibrous Scaffold in Bone Tissue Engineering

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