口腔医学研究

口腔医学研究 ›› 2015, Vol. 31 ›› Issue (12): 1220-1222.

• 临床研究论著 • 上一篇    下一篇

α通过血清中TNF-α、IL-17、IL-23的水平研究慢性牙周炎和类风湿性关节炎的相关性

朱建华,杨艳飞,李晓光,刘继光*   

  1. 黑龙江省佳木斯市佳木斯大学附属第二医院口腔医院牙周科 黑龙江 佳木斯 154002
  • 收稿日期:2015-05-26 出版日期:2015-12-28 发布日期:2016-03-21
  • 通讯作者: 刘继光,E-mail:13694668555@163.com
  • 作者简介:朱建华(1959~),女,黑龙江佳木斯人,教授,主要从事牙周黏膜方面的研究。
  • 基金资助:
    佳木斯大学研究生科技创新项目(编号:LZZ2015_020)

Correlation between Periodontitis and Rheumatoid Arthritis through the Levels of TNF-α,IL-17,IL-23 in Serum.

ZHU Jian-hua, YANG Yan-fei, LI Xiao-guang, LIU Ji-guang.   

  1. Department of Periodontology, The Second Affiliated Hospital of Jiamusi University. Jiamusi 154002, China
  • Received:2015-05-26 Online:2015-12-28 Published:2016-03-21

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摘要： 目的:探讨肿瘤坏死因子(TNF-α)、白介素-17(IL-17)、 白介素-23(IL-23)在类风湿性关节炎(RA)与慢性牙周炎中的含量其临床意义。方法:按纳入标准选取类风湿性关节炎患者(R)28人、慢性牙周炎患者(P)32人、类风湿性关节炎伴牙周炎患者(R+P)22人和健康对照组(H)18人使用ILISA方法检测分析血清中的TNF-α、IL-17、IL-23含量。结果:慢性牙周炎组、类风湿性关节炎组、类风湿性关节炎伴慢性牙周炎组血清中TNF-α、IL-17、IL-23的含量明显高于健康对照组(P＜0.05);类风湿性关节炎伴慢性牙周炎组血清中TNF-α、IL-17、IL-23明显高于慢性牙周炎组,类风湿性关节炎组的含量(P＜0.05);慢性牙周炎组、类风湿性关节炎组含量无明显差异,无统计学意义。结论:TNF-α、IL-17、IL-23可能在牙周病和RA的相互关系中发挥重要作用,引起牙周炎的致炎因素也可以影响类风湿性关节炎。

关键词: 类风湿性关节, 牙周炎, 白介素-17, 白介素-23, 肿瘤坏死因子

Abstract: Objective: To investigate the levels of the tumor necrosis factor (TNF-α), interleukin -17 (IL-17), interleukin -23 (IL-23) and their clinical significance in rheumatoid arthritis (RA) and chronic periodontitis. Methods: Twenty-eight rheumatoid arthritis (R) patients, 32 chronic periodontitis (P) patients, 22 rheumatoid arthritis and periodontitis (R+P) patients and 18 healthy persons (H) were selected according to the inclusion criteria. ELISA was used to detect the levels of TNF-α, IL-17, IL-23 in serum. Results: The levels of TNF-α, IL-17, IL-23 in groups P, H, and P+H were significantly higher than those of the control group (P<0.05); and the levels of TNF-α, IL-17, IL-23 in group P+H were significantly higher than those in group P and H (P<0.05). There was no significant difference between the group of P and H. Conclusion: TNF-α, IL-17 and IL-23 may be used as factors linking periodontal disease rheumatoid arthritis.

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