口腔医学研究

口腔医学研究 ›› 2015, Vol. 31 ›› Issue (12): 1251-1253.

• 临床研究论著 • 上一篇    下一篇

幽门螺杆菌感染与汉族非吸烟人群牙周病患病风险的病例对照研究

李静1*,施俊2   

  1. 1. 西安交通大学口腔医院第一诊所 陕西 西安 710048;
    2. 湖北医药学院附属太和医院 湖北 十堰 442000
  • 收稿日期:2015-06-10 出版日期:2015-12-28 发布日期:2016-03-21
  • 通讯作者: 李静,电话:(029)82220005
  • 作者简介:李静(1970~),女,陕西人,住院医师,硕士研究生,主要从事牙周病的临床治疗工作。

Association of Helicobacter Pylori Infection and Periodontal Disease Risk in Nonsmoking Chinese Han Population: a Case-control Study.

LI Jing1, SHI Jun2.   

  1. 1. The First Clinic, Stomatology Hospital, Xi'an Jiao Tong University, Xian 710048, China;
    2. Affiliated Taihe Hospital, Hubei Medical and Pharmacy College. Shiyan 442000, China
  • Received:2015-06-10 Online:2015-12-28 Published:2016-03-21

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摘要： 目的:采用病例-对照研究探讨汉族非吸烟人群幽门螺杆菌感染和牙周病患病风险之间的相关性。方法:使用尿素酶检测试剂盒对2013年6月~2015年3月确诊的85例牙周病患者和91例健康对照人群进行幽门螺旋杆菌阳性率的检测。两组间的基线情况及幽门螺杆菌感染与牙周病相关性采用SPSS19.0软件进行分析,并计算校正后的结果。结果:两组间基线可比性好。结果表明,幽门螺旋杆菌的阳性率使牙周病的发生风险提升了3.23倍(OR=3.23,95%CI=1.63-6.41);校正年龄、性别、饮酒史和糖尿病史后,罹患风险依然显著提高了2.47倍(OR=2.47, 95%CI=1.35-4.52)。结论:牙周病与幽门螺旋杆菌感染的关系密切,幽门螺旋杆菌可能是牙周病患病的独立显著性标志物。

关键词: 牙周病, 牙周炎, 幽门螺旋杆菌, 病例-对照研究

Abstract: Objective: To explore the association of Helicobacter pylori (HP) infection with periodontal disease (PD) risk in nonsmoking Chinese Han population. Methods: Eighty-five PD patients and 95 healthy controls from June 2013 to March 2015 were included in this study. Urease Activity Assay Kit was used to detect the positive rate of HP infection in all of the participants. Differences of basic features and the association of HP infection and PD risk were calculated by SPSS19.0. Age, gender, drinking, and diabetes history were used as confounding factors to adjust the results. Results: Basic features were significantly different between case and control groups. Association analysis showed that high HP positive rate could increase the PD risk by approximately 3.23 folds (OR=3.23,95%CI=1.63-6.41). After adjusted by age, gender, drinking and diabetes history, the association was also statistically significant (OR=2.47, 95%CI=1.35-4.52). Conclusion: PD was significantly associated with the HP infection. HP might act as an independent and significant marker for PD.

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