Journal of Oral Science Research ›› 2016, Vol. 32 ›› Issue (1): 5-7.DOI: 10.11839/kqyxzh.2016.01.002

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E3 Ubiquitin Ligase RNF126 Regulates the Invasion of Tongue Cancer Cells.

LIU Yu1, YIN Wei2, ZHAO Yue-han3, SHI Chun3.   

  1. 1. Department of Stomatology, The Fifth People’s Hospital of Dalian, Dalian 116021, China;
    2. The State Key Laboratory Breeding Base of Basic Science of Stomatology & Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan 430079, China;
    3. School of Stomatology, Dalian Medical University, Dalian 116021, China
  • Received:2015-10-20 Online:2016-01-28 Published:2016-03-21

Abstract: Objective: To investigate the effects of RNF126 on tumorigenesis of tongue cancer. Methods: The cell proliferation of SCC25 was determined by MTT. Single cell variation of SCC25 was determined by colony formation assay. The migration ability was analyzed by Transwell assay. Results: Overexpression of RNF126 promoted the proliferation of SCC25 cell, while inhibition of RNF126 decreased the SCC25 cell growth. Inhibition of RNF126 also decreased the migration ability of SCC25 cell. Conclusion: These data suggested that RNF126 might be related to the invasion of tongue cancer.

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