Expression and Correlation of Naa10p and PrPc in Oral Squamous Cell Carcionoma.

doi:10.13701/j.cnki.kqyxyj.2016.05.014

Abstract

Abstract: Objective: To detect the expression and clinical significance of N-α-acetyltransferase10 protein (Naa10p) and cellular prion protein (PrPc) in oral squamous cell carcinoma (OSCC), oral leukoplakia and normal oral mucosa. Methods: The expressions of Naa10p and PrPc were detected by immunohistochemistry assay (EnvisionTM) in OSCC (112 cases), leukoplakia (42 cases) and normal mucosa tissues (11 cases), and the correlation between their expression and clinical features was analyzed. Results: The expression level of Naa10p and PrPc was the highest in OSCC, followed by leukoplakia, and the lowest in normal mucosa tissues. Naa10p expression in three different tissues was statistically significant (P<0.05). PrPc expression was significantly different in OSCC compared to oral leukoplakia and normal tissues (P<0.05), while there was no difference between oral leukoplakia and normal mucosa. In addition, Naa10p expression was correlated with TNM stage, lymph node metastasis and cell differentiation of patients with OSCC (P<0.05), but was not associated with gender and age. Moreover, PrPc expression was only positively correlated with cell differentiation in OSCC (P<0.05), while Naa10p expression was negatively correlated with cell differentiation (P<0.05). Conclusion: Naa10p and PrPc are associated with the tumorgenesis and metastasis of OSCC.

CLC Number:

R739.8

ZHENG Jun, XU Jiang, YU Xin-le, ZHANG Jie, YANG Yang, ZHANG Kai-nan, ZENG Yan.. Expression and Correlation of Naa10p and PrPc in Oral Squamous Cell Carcionoma.[J]. Journal of Oral Science Research, 2016, 32(5): 483-486.

References

[1] 张杰,曾妍,郑军,等.朊蛋白在15腔鳞状细胞癌和黏膜白斑中的表达及意义[J].中华口腔医学杂志,2013,48(12)∶752-754
[2] 张宏宇,李善昌,仲琦,等. L-选择素在口腔鳞状细胞癌组织和涎腺恶性肿瘤组织中的表达及其相关性的研究[J].口腔医学研究,2014,30(10)∶953-957
[3] YANG X J. The diverse super family of lysine acetyltransferases and their roles in leukemia and other diseases [J]. Nucleic Acids Res, 2004, 32(3)∶959 -976
[4] Arnesen T, Anderson D, Baldersheim C, et al. Identification and characterization of the human naa10p -nath protein acetyltransferase complex [J]. Biochem J, 2005,386(3)∶433 -443
[5] 张天亮,吴润,杨润霞,等.朊蛋白在癌症发生中的作用[J].动物医学进展,2015,36(6)∶145-150
[6] Wang ZH, Gong JL, Yu M, et al.Up-regulation of human arrest-defective 1 protein is correlated with metastatic phenotype and poor prognosis in breast cance [J]. Asian Pac J Cancer Prev,2011,12(8)∶1973-1977
[7] Shin DH, Chun YS, Lee KH, et al. Arrest Defective-1 controls tumor cell behavior by acetylating myosin light chain kinase [J]. PLoS One,2009,4(10)∶e7451
[8] Diarra-Mehrpour M, Arrabal S, Jalil A, et al.Prion protein prevents human breast carcinoma cell line from tumor necrosis factor α-induced cell death [J]. Cancer research, 2004, 64(2)∶719-727
[9] Kim BH, Lee HG, Choi JK, et al. The cellular prion protein (PrPc) prevents apoptotic neuronal cell death and mitochondrial dysfunction induced by serum deprivation [J]. Brain Res Mol Brain Res,2004,124(1)∶40-50
[10] Pan Y, Zhao L, LiangJ, et al. Cellular prion protein promotes invasion and metasta -sis of gastric cancer [J]. The FASEB Journal,2006, 20(11)∶1886-1888
[11] Liang J, Pan Y, Zhang D, et al. Cellular prion protein promotes proliferation and G1/S transition of human gastric cancer cells SGC7901 and AGS [J]. FASEB J,2007,21(9)∶2247-2256

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[3]	QIN Shuai-hua,LI Xin-ming,LI Wen-lu. Analysis of Influencing Factors of Life Quality of Patients with Oral Cancer after Reconstruction [J]. Journal of Oral Science Research, 2018, 34(2): 144-147.
[4]	DENG Xuan, YANG Fang. Influence of MUC1-siRNA on Migration, Invasion, and PI3K-Akt Signaling Pathway of Human Tongue Cancer Tca Cells [J]. Journal of Oral Science Research, 2018, 34(2): 148-151.
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[8]	ZHOU Xiong-ming, NA Si-jia, PAN Shu-ting, QIU Jia-xuan. Effect of Plumbaginon on Invasion and Migration of Tongue Squamous Cell Carcinoma Cells and Its Mechanism [J]. Journal of Oral Science Research, 2018, 34(1): 39-43.
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[14]	WU Li-bo, PAN Shu-ting, QIU Jia-xuan.. Expression Level and Clinical Efficacy of Multidrug Resistant Proteins before and after Neoadjuvant Chemotherapy in OSCC. [J]. Journal of Oral Science Research, 2017, 33(12): 1298-1301.
[15]	WANG Li-ping, GUO Xue-qi, YAN Yong-yong, ZHA Jun, CHEN Wei-hong, WEI Yong-xiang, ZHU Xin-xin, GUAN Hong-bing, GE Lin-hu. Effect and Functioanl Role of miR-146a in Oral Squamous Cell Carcinoma Tissues and Cell Lines [J]. Journal of Oral Science Research, 2017, 33(11): 1204-1208.