TLRs and NLRs Synergistically Promote the Maturation of Dendritic Cells.

doi:10.13701/j.cnki.kqyxyj.2017.07.007

Abstract

Abstract: Objective: To study the effect of TLRs and NLRs on the maturation of dendritic cells. Methods: The DC2.4 cells were stimulated with a single ultrapure TLR/NLR ligand or a combination of two ligands. After 24 hours, the flow cytometry was used to test the expression of CD40, CD83, CD86, CD80, and MHC-Ⅱon the surface of DCs. Results: A single TLR or NLR ligand could promote the expression of DCs surface markers, and the combined stimulation of two ligands could enhance the expression of the above markers. Conclusion: TLRs and NLRs can synergistically promote the maturation of DCs.

Key words: Dendritic cells (DCs), TLRs, NLRs, Marker molecules

CLC Number:

R780.1

LIN Zhen, LI Yu-hong.. TLRs and NLRs Synergistically Promote the Maturation of Dendritic Cells.[J]. Journal of Oral Science Research, 2017, 33(7): 717-720.

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TLRs and NLRs Synergistically Promote the Maturation of Dendritic Cells.

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