Comparison of 8-OHdG in Whole Unstimulated Saliva Obtained from Patients with Different Types of Periodontitis.

doi:10.13701/j.cnki.kqyxyj.2017.08.024

Abstract

Abstract: Objective: To evaluate the content of 8-hydroxydeoxyguanosine (8-OHdG) in whole unstimulated saliva from patients with different types of periodontitis and the relationship between 8-OHdG and clinical parameters. Methods: Whole unstimulated saliva samples were collected from 10 healthy control subjects (H), 10 chronic periondontitis (CP) and 10 aggressive periodontitis (AgP) patients. To determine the clinical condition of each subject, the plaque index (PLI), sulcus bleeding index (BI), clinical attachment level (CAL), and probing depth (PD) were measured. The salivary 8-OHdG level was measured using ELISA method. Results: Higher salivary 8-OHdG level was found among three groups (P<0.05). The results showed that the 8-OHdG levels were in the rank of Agp group > CP group > H group. The 8-OHdG has a relationship with all clinical parameters. In the CP and AgP groups the 8-OHdG has a relationship with CAL. Conclusion: The level of 8-OHdG in salivary indicates the periodontal status and has a relationship with peridontitis type.

Key words: 8-OHdG , Salivary, Periodontitis

CLC Number:

R781.4

ZHANG Meng-jun, LUAN Qing-xian.. Comparison of 8-OHdG in Whole Unstimulated Saliva Obtained from Patients with Different Types of Periodontitis.[J]. Journal of Oral Science Research, 2017, 33(8): 898-900.

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