Effect of Chronic Apical Periodontitis on Plasma Cytokine and Aorta Intima in Rats

doi:10.13701/j.cnki.kqyxyj.2019.09.013

Abstract

Abstract: Objective: To investigate the effect of chronic apical periodontitis (CAP) for 12 weeks on rat plasma cytokines response and lesion of aorta. Methods: 32 male SD rats were randomly divided into high fat diet group and normal diet group. After 9 weeks, according to the teeth number of opening pulp cavity, the rats were divided into four groups (n=8) to build CAP model, namely N0, N6, H0 and H6. After 24 weeks, plasma concentrations of lipid (TC, TG, HDL-C, LDL-C) and inflammation cytokine (CRP, IL-2, IL-6, IL-10) were detected. Histological examinations of aorta were performed by HE staining and sudan Ⅳ staining. Results: There were no significant difference in plasma CRP, IL-2, IL-6 and IL-10 among four groups (P>0.05). Aorta intima was smooth without obvious inflammation cell adhesion in N0 group. A small amount of inflammatory cells were found in muscularis and adventitia among N6, H0 and H6 groups. Conclusion: CAP for 12 weeks on rats did not raise plasma concentration of cytokine, neither did it when combined with hyperlipidemia. CAP infection caused slight inflammatory cells infiltration in rat aorta.

Key words: chronic apical periodontitis, cytokine, aorta

MA Dianfu, CHEN Shuai, XIAO Suli, LI Pingping, HUANG Xiaojing. Effect of Chronic Apical Periodontitis on Plasma Cytokine and Aorta Intima in Rats[J]. Journal of Oral Science Research, 2019, 35(9): 872-875.

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