Abstract: Objective: To explore the clinical characteristics, diagnosis, and treatment of ameloblastic carcinoma (AC) by analyzing clinical cases and reviewing the literature. Methods: The clinical data of 14 patients with AC were retrospectively analyzed. Results: There were 10 male and 4 female patients included in this study, with a male-to-female ratio of 2.5∶1. Their ages ranged from 15 to 71 years and the mean age was 40.9 years. Six patients' lesion location was maxilla and 8 patients' was mandible, and the maxilla-to-mandible ratio was 0.75∶1. All patients were subjected to surgical resection and followed-up for 0.5-7 years to record recurrence. There were 9 recurrences in the case series, of which 1 had cervical lymph node metastasis, and 2 had lung metastasis after surgery. Conclusion: AC is a rare neoplasm of the odontogenic epithelium. Secondary AC is mostly caused by repeated surgical intervention. Recurrence rate of AC is closely related to lesion location and treatment. At present, extended surgical resection is still the preferred treatment and postoperative long-time followed-up is necessary.

Key words: ameloblastic carcinoma, clinical manifestations, diagnosis, treatment