Mandibular Bone Regeneration: Evolving Strategies in Tissue Engineering Scaffold Design

doi:10.13701/j.cnki.kqyxyj.2026.06.001

Abstract

Abstract: The mandible is a vital component of the craniofacial bone. Due to its critical biomechanical roles, unique intramembranous ossification process, high bone remodeling activity, and the robust osteogenic potential of mandibular bone marrow mesenchymal stem cells (BMSCs), tissue engineering strategies for mandibular repair present distinct challenges compared to those used for long bones. This review provides a systematic overview of key strategies and technological advances in mandibular tissue engineering. It covers scaffold materials and design, bioactive enhancement approaches, current research challenges, and the emerging potential of 4D printing and related technologies. The objective of this review is to offer a theoretical foundation and technical guidance for the development of effective, safe, and functionally integrated regenerative solutions for mandibular bone defects.

Key words: mandibular defect repair, tissue engineering, stent, 4D printing technology

LI Dongyang, LI Jun. Mandibular Bone Regeneration: Evolving Strategies in Tissue Engineering Scaffold Design[J]. Journal of Oral Science Research, 2026, 42(6): 461-466.

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