Abstract: Objective: To determine the effectiveness of periodontal therapy on serum C-reactive protein in CHD patients with chronic periodontitis reported by articles and to assess the quality of the studies by evidence-based medicine(EBM). Methods: The databases such as CNKI, wanfangdata, VIP, CBM published from the 1994 to 2013 were searched. All published literatures about the effectiveness of periodontal therapy on serum C-reactive protein in CHD patients with chronic periodontitis were collected. Literatures were screening and the data were extracted in accordance with inclusion criteria. Literature based on evidence-based medicine was analysed. Results: There were totally 15 articles that met the criteria. Randomized controlled trials (RCT) was in a small number and low research quality. Meta-analysis could not be done. The results showed that: for now, periodontal therapy may reduce the levels of serum C-reactive protein in CHD patients with chronic periodontitis. Conclusion: There are not enough articles about the effectiveness of periodontal therapy on serum C-reactive protein in CHD patients with chronic periodontitis. The quantity and quality of the reviewed studies are far from satisfaction and can not meet the clinical needs. Further trials of high methodological quality need to be undertaken in order to guide the effectiveness of periodontal therapy on serum C-reactive protein in CHD patients with chronic periodontitis.

Key words: Chronic periodontitis, CHD, Periodontal therapy , C-reactive protein, Evidence-based medicine