Expression of IL-6 in Periodontal Tissue during Orthodontic Relapse in Rats

doi:10.13701/j.cnki.kqyxyj.2016.11.010

Abstract

Abstract: Objective: To study the expression of inflammatory cytokines interleukin IL-6 in rat periodontal tissues during orthodontic relapse. Methods: Thirty male Wistar rats were randomly divided into normal control group (6) and orthodontic tooth movement model group (24). Devices of the model group were removed after 14 days with rats randomly divided into model-0 day, model-7 day, model-14 day, and model-21 day group. Animals were sacrificed on day 0, day 7, day 14 and day 21, respectively. Then, periodontal tissues were obtained to detect the changes of inflammatory cytokines IL-6 in protein and gene expression levels. Results: Compared with the control group, protein and gene expression levels of IL-6 in Model-0 day group did not change significantly (P>0.05). But the expression level of IL-6 protein and gene on Model-7 day increased significantly and reached the highest (P<0.05). The expression level of IL-6 protein and gene on Model-14 day was higher than the control group, but a little lower than the Model-7 day. The expression level of IL-6 protein and gene on Model-21 day significantly decreased when compared to the Model-7 day, and was close to the control group (P>0.05). Conclusion: The expression levels of IL-6 protein and gene significantly increased in the condition of rat orthodontic relapse, arrived the top level on Model-14 day, and then decreased gradually.

Key words: Orthodontic relapse, Orthodontic tooth movement, Interleukin-6, Periodontal tissue

CLC Number:

R783.5

GAO Rui, AN Jing-tao, SONG Bing, SHAO Ping. Expression of IL-6 in Periodontal Tissue during Orthodontic Relapse in Rats[J]. Journal of Oral Science Research, 2016, 32(11): 1153-1155.

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