Correlative Study on Expression of Saliva Matrix Metalloprotase 9 in Patients with Sjogren Syndrome and Histopathologic Grading.

doi:10.13701/j.cnki.kqyxyj.2017.12.016

Abstract

Abstract: Objective: To research the expression of matrix metalloprotase 9 (MMP-9) in the saliva and the relationship with histopathologic grading of patients with Sjogren Syndrome. Methods: The expressions of MMP-9 in the saliva of 27 Sjogren Syndrome patients (experimental group) and 29 underlip mucocele patients (control group) were detected with ELISA and the results of Sjogren Syndrome patients were pathological graded with low level (1 and 2) and high level (3 and 4). Results: In contrast to control group, the MMP-9 levels in Sjogren Syndrome patients were significantly increased (P<0.05), and the level of MMP-9 in the high pathologic grade was higher than that of low grade (P<0.05). Conclusion: The level of MMP-9 in the saliva may be a test indicator for the Sjogren Syndrome, which might provide reference for clinical diagnosis and treatment.

Key words: Sjogren syndrome, Saliva , MMP-9 , Pathological grading

CLC Number:

R780.2

Xia Ping, Zhang Mei-xi, Mu Sen, Zhang Rui-jie, Chai Lin, Zhan Yuan-bo, Zhang Rui-min.. Correlative Study on Expression of Saliva Matrix Metalloprotase 9 in Patients with Sjogren Syndrome and Histopathologic Grading.[J]. Journal of Oral Science Research, 2017, 33(12): 1302-1305.

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