Influence of Corticotomy on Safety of Orthodontic Tooth Movement via Promoting Osteogenesis in Rats.

doi:10.13701/j.cnki.kqyxyj.2017.04.006

Abstract

Abstract: Objective: To study the influences of corticotomy on orthodontic tooth movement (OTM) and the underlying mechanism in rats. Methods: Forty-eight female Sprague-Dawley rats were randomly assigned to corticotomy group (Cort, 24 rats) and sham-corticotomy group (Sham, 24 rats). All rats were subjected OTM after corticotomy or sham surgery. Six rats of each group were executed on day 0, 1, 3 and 7 of OTM. OTM were measured with an electronic digital caliper. New-formed bone was counted on the intension side with HE staining. Osteocalcin and Runx2 were measured by IHC on the tension side. Data were analyzed with the SPSS software version 16.0 and P<0.05 was considered as statistically significant. Results: OTM on day 1 and 7 in the Cort group increased when compared to the sham group. New-formed bone on the tension side increased in the Cort group on day 3 and 7. Osteocalcin positive osteoblasts on the tension side also increased in the Cort group on day 3 and 7. Expression of Runx2 increased on the tension side in the Cort group on day 3 and 7. Conclusion: Corticotomy accelerated OTM in rats and the promoted bone formation may guarantee the safety of OTM in rats.

Key words: Corticotomy , Orthodontic tooth movement , Osteoblast Runx2

CLC Number:

R783.5

ZHU Shao-yue, LIU Zong-xiang, LI Xiao-ming,LIU Hao, WANG Peng-lai.. Influence of Corticotomy on Safety of Orthodontic Tooth Movement via Promoting Osteogenesis in Rats.[J]. Journal of Oral Science Research, 2017, 33(4): 371-374.

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