Expression of Wnt10b and RANKL in the Pressure Site of Periodontal Tissue under Orthodontic Force.

doi:10.13701/j.cnki.kqyxyj.2016.03.011

Abstract

Abstract: Objective: To investigate the changes of RANKL and wnt10b in the periodontal tissue during orthodontic tooth movement. Methods: 〖WT5”BZ〗Forty two healthy male SD rats were randomly divided into 7 groups according to the application loaded time points of 0h, 6h, 12h, 24h, 5d, 7d, and 14d. The group of 0h served as control and the Nickel-titanium closed-coils springs were used to produce 50g power to drag the first molars mesially. Real-time PCR (RT-PCR) technology was used to detect the expression of Wnt10b and RANKL. Results: 〖WT5”BZ〗RANKL and Wnt10b were both expressed in the pressure site in comparison with the control group according to the results of the RT-PCR. The expression of wnt10b mRNA was suppressed at the early stage, then increased, and reached the peak after 5-7 days. It returned to the normal level after 14 days. The expression of RANKL elevated at first, then peaked after 5-7 days, and decreased. Conclusion: 〖WT5”BZ〗Wnt10b and RANKL participated in periodontal tissue remodeling under the action of the orthodontic force.

Key words: Orthodontic tooth movement , Osteoclast differentiation , Periodontal tissue remodeling , Wnt10b , RANKL

CLC Number:

R783.5

WANG Ying, WANG Lan-zhu, HAN Bo, WU Ming-ming, ZHANG Miao-miao. Expression of Wnt10b and RANKL in the Pressure Site of Periodontal Tissue under Orthodontic Force.[J]. Journal of Oral Science Research, 2016, 32(3): 257-260.

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