Observation of Mongersen's Anti-inflammatory Effect on Periodontitis Rat

doi:10.13701/j.cnki.kqyxyj.2020.04.018

Abstract

Abstract: Objective: To investigate the anti-inflammatory effect of mongersen on periodontitis in rat. Methods: A total of 22 healthy male Wistar rats aged 8 weeks were randomly selected. The models of periodontitis were established in 16 rats which were randomly divided into 3 groups, group M (mongersen), group N (saline), and group C (negative controls), the remaining 6 rats were Group C0 (no intervention). All drugs were injected into the rat's maxillary buccal and palatine side of gingival via a microsyringe. Two weeks later, clinical parameters and morphological analysis were measured, then all rats were sacrificed, and the histological changes of periodontal tissues in each group were observed by HE stain and the expression of inflammatory cytokines in gingival tissues of rats were detected by qRT-PCR. Results: Clinical indicators and histological observation showed that in Group M the inflammation was alleviated compared with the group N and C. The qRT-PCR results showed that the gene expressions of TNF-α, IL-1β, IL-6, and INOS in the group M were significantly decreased compared with those of group N and C (P<0.001). Conclusion: Mongersen has anti-inflammatory effect on periodontitis rat.

Key words: Mongersen, periodontitis, immunity

DING Xiaohan, YUE Yiyun, XIA Boyuan, LI Yan, LIU Xinchan, WU Zhou, YU Weixian. Observation of Mongersen's Anti-inflammatory Effect on Periodontitis Rat[J]. Journal of Oral Science Research, 2020, 36(4): 382-386.

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