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28 May 2020, Volume 36 Issue 4 Previous Issue    Next Issue

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Advancement of Cancer-associated Fibroblasts in Oral Squamous Cell Carcinoma HU Qingang, ZHAO Xingxing 2020, 36(4): 309-313.  DOI: 10.13701/j.cnki.kqyxyj.2020.04.001 Abstract ( 391 )   PDF (1021KB) ( 469 )   Oral squamous cell carcinoma (OSCC) is the most common malignant tumor in the head and neck, and cancer-associated fibroblasts (CAFs) are the most important stromal cells in the tumor microenvironment as similar with other malignancies. CAFs were critically involved in the proliferation, metastasis, immune tolerance, and treatment resistance of tumor cells. This paper aims to summarize the recent progress of CAFs in OSCC and its enlightenment for clinical treatment. Targeting CAFs for therapeutic intervention and breaking the essential microenvironment barrier to suppress the growth and migration of tumor cells, effectively block angiogenesis,and enhance immune responses may provide a novel insight and strategies for the adjuvant therapy of OSCC. References | Related Articles | Metrics

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Comprehensive Review of Malignant Hyperthermia in the Diagnosis and Treatment of Stomatology ZHOU Jiang, TANG Zhangui 2020, 36(4): 314-317.  DOI: 10.13701/j.cnki.kqyxyj.2020.04.002 Abstract ( 244 )   PDF (881KB) ( 201 )   Malignant hyperthermia (MH) was firstly discovered and described in 1960 by Denborough and Lovell in Australia. This was a rare and potentially lethal skeletal muscle hypermetabolic response disease, recognized as an autosomal dominant inheritance. This disease was usually caused by volatile anesthetics or depolarizing muscle relaxants. Moreover, it could also be triggered by other factors, such as strenuous exercise and emotional stress. Studies have shown that MH patients could have mutations in RYR1, CACNA1S, STAC3, and other gene mutations, among which the RYR1 gene mutations occupied the major proportion and male patients were more than female patients. The main clinical manifestations of MH were masseter muscle spasm, elevated partial pressure of carbon dioxide at the end of the breath, and a rapid and continuous rise of body temperature. In the stomatology, MH should be considered sooner if symptoms such as masseter muscle spasm occurred. Therefore, it is important for dentist to improve the ability to diagnose and treat MH. The incidence of MH is increasing steadily in recent years in China and the specific drug Dansalin is still difficult to obtain. Therefore, it is necessary to develop a series of effective treatment measures and standards. In this review, the latest research progress of MH is introduced and summarized. References | Related Articles | Metrics

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Study on Effects of Butyric Acids on Periodontitis ZANG Wenli, LIU Junchao, PAN Yaping 2020, 36(4): 318-320.  DOI: 10.13701/j.cnki.kqyxyj.2020.04.003 Abstract ( 347 )   PDF (817KB) ( 432 )   Periodontitis is a chronic infectious disease of periodontal support tissue caused by plaque microorganisms. Plaque biofilm is the initiator of periodontitis. In recent years, periodontal pathogens metabolizing amino acids, hexose or anaerobic glycolysis, a metabolite produced by pentose, butyric acid, have attracted widespread attention. The development of butyric acid in periodontitis plays an important role. The butyric acid in the gingival crevicular fluid of patients with periodontitis was significantly higher than that of the healthy group. The high concentration of butyric acid in the oral cavity of periodontal patients may destroy the structure and function of periodontal tissue. This article reviews the effects of butyric acid on periodontitis. References | Related Articles | Metrics

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Progress on Horizontal Augmentation of Posterior Mandible XU Hongwei, CHU Shunli. 2020, 36(4): 321-323.  DOI: 10.13701/j.cnki.kqyxyj.2020.04.004 Abstract ( 300 )   PDF (768KB) ( 334 )   Periodontal disease and other diseases often lead to the loss of teeth. Implant repair has become an important way to deal with this problem. In the process of implantation, insufficient horizontal bone due to alveolar bone resorption of mandible will adversely affect the repair process. In this paper, several common methods and their advantages and disadvantages for horizontal augmentation of the posterior mandible are reviewed. References | Related Articles | Metrics

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Research Progress of Mandibular Advancement Device in Treatment of Adult Obstructive Sleep Apnea Hypoxia Syndrome ZHU Dechao, LU Haiyan 2020, 36(4): 324-327.  DOI: 10.13701/j.cnki.kqyxyj.2020.04.005 Abstract ( 275 )   PDF (787KB) ( 348 )   Mandibular advancement device is one of oral appliances for obstructive sleep apnea hypoxia syndrome. It has the advantages of convenience, comfort, and low cost. And its structural characteristics are also diverse. More comprehensive efficacy evaluation and less side effects should be implemented to make the mandibular advancement device more widely used. This article reviews the recent advances in the treatment of OSAHS with mandibular advancement device. References | Related Articles | Metrics

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Role of Anti-PD-L1 Therapy in Lymphatic Malformations Rat Models JIANG Hao, ZHONG Wenqun, ZOU Yanping, LI Xuecong, CAI Yu 2020, 36(4): 328-332.  DOI: 10.13701/j.cnki.kqyxyj.2020.04.006 Abstract ( 259 )   PDF (7729KB) ( 124 )   Objective: To observe the effect of Anti-PD-L1 therapy in established LMs rat models. Methods: LMs rat models were established by injection of Freund's incomplete adjuvant (FIA) in subcutaneous to the neck in twenty female Wistar rats [(250 ± 30) g]. Rats with lesions were randomly divided into four groups with different treatment as follows: PBS only, PBS and Anti-PD-L1, PBS and LPS or PBS combination with LPS and Anti-PD-L1. The sizes of LMs lesions and body weight of rats were measured for every week. After eight weeks, all rats were euthanized and the cystic lesions and vital visceral organs were harvested for further investigation. Expression level of PD-L1 in normal skins and human LMs was detected by immunohistochemistry. Results: PD-L1 was strongly elevated in the LM lesions of rats and further increased in the presence of LPS. Anti-PD-L1 therapy showed satisfactory therapeutic effect on both non-inflammatory and inflammatory LMs by decreasing the proliferation and tubular formation of lymphatic endothelial cells. In addition, compared with normal skins, PD-L1 was also upregulated in human LM lesions. Conclusion: PD-L1 might contribute to the pathological process of lymphatic malformations. Targeting the PD-L1 might be a promising therapeutic strategy for LMs. References | Related Articles | Metrics

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Correlation between Disc Perforation and Condylar Bone Changes Based on Temporomandibular Joint Arthrography by CBCT ZHANG Ying, FENG Zijun, LI Xingyang, WANG Zhaojian. 2020, 36(4): 333-336.  DOI: 10.13701/j.cnki.kqyxyj.2020.04.007 Abstract ( 229 )   PDF (1222KB) ( 277 )   Objective: To investigate the correlation between temporomandibular joint disc perforation and condylar bone changes. Methods: A total of 224 patients with temporomandibular joint arthrography were taken CBCT in our hospital for temporomandibular joint disorders. According to the arthrography results, the patients were divided into four groups, which were disc perforation with condylar bone changed group, disc perforation and condylar bone unchanged group, disc unperforated and condylar bone unchanged group, articular disc not perforated and condylar bone changed group. We explored the relevance between disc perforation and condylar bone changes. Results: There was a significant correlation between temporomandibular joint disc perforation and condylar bone changes (OR=21.28,P<0.05). Among the eight types of condylar bone changes, condylar hyperosteogeny was the most relevant to disc perforation(OR=4.22,P<0.05). Conclusion: There is a significant correlation between temporomandibular joint disc perforation and condylar bone changes. Condylar hyperosteogeny is most likely to be associated with perforation, but the order of perforation of the disc and condylar bone changes remains to be further studied. References | Related Articles | Metrics

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Correlational Study on Occlusal Interferences and Temporomandibular Disorders ZOU Daoxing, WANG Zengquan, LU Yu 2020, 36(4): 337-340.  DOI: 10.13701/j.cnki.kqyxyj.2020.04.008 Abstract ( 271 )   PDF (1550KB) ( 298 )   Objective: To analyze the occlusal features of temporomandibular disorders (TMD) patients with Angle class II division 1 malocclusion, and explore the correlation between occlusal interferences and temporomandibular disorders. Methods: 60 Angle class II division1 malocclusion patients with TMD were selected as experimental group,60 Angle class II division1 malocclusion patients without TMD were set as control group. The degree of oral and facial discomfort was evaluated by visual analog scale. Temporomandibular dysfunction index was calculated to compare the symptoms between TMD patients with OI and without OI. Temporomandibular dysfunction index(dysfunction index, DI) includes mandibular movement(mandibular movement, MM),joint noise(joint noise, JN), and joint palpation (joint palpation, JP). Results: There were 45 occlusal interferences patients in experimental group and 42 occlusal interferences patients in control group (P＞0.05). In experimental group, the dysfunction index and the visual analog scale score of TMD patients with occlusal interferences was higher than those of TMD patients without occlusal interferences(P<0.01). The dysfunction index of female patients was higher than that of male patients. Conclusion: There was no direct connection between occlusal interferences and TMD,but TMD patients together with occlusal interferences could aggravate the patients’ symptoms. The existence of occlusal interferences could be a threat to the health of stomatognathic system. References | Related Articles | Metrics

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Clinical Study of Decompression Combined with Curettage for Unicystic Ameloblastoma ZHANG Ligang, YI Jie, YAO Li, HUANG Guilin, HU Xiaohua, ZHANG Nini, DAI Min 2020, 36(4): 341-345.  DOI: 10.13701/j.cnki.kqyxyj.2020.04.009 Abstract ( 220 )   PDF (3761KB) ( 566 )   Objective: To investigate the efficacy and prognosis of decompression combined with curettage for unicystic ameloblastoma. Methods: 20 cases of unicystic ameloblastoma were treated with decompression. The cyst plug with soft liner thermosetting resin was used to keep the wound open and a second stage curettage was performed. The changes of tumor cavity were observed after the operation. Results: Patient imaging showed that the lesion range was significantly reduced, and the anatomy of the lesion area was close to normal. The tumor cavity decreased by 28.66% on average 3 months after operation, and decreased by 58.51% on average 6 months, decreased by 79.33% on average 12 months. After the surgery, the sizes of the tumor cavity shrank, all these had statistical significance (P＜0.05). Then 6 months later, the bone mineral densities at coronal and sagittal and horizontal respectively were 371.32 Hu, 361.74 Hu, and 384.71 Hu. Followed-up 12 months, the bone mineral densities increased to 517.64 Hu, 523.22 Hu, and 521.05 Hu (P＜0.05). The second stage curettage was performed 12 to 24 months after operation. No recurrence of tumor was observed in the 3 to 5 years of follow up. Conclusion: It is an effective method for the treatment of unicystic ameloblastoma by decompression combined with curettage. And the cyst plug with soft liner thermosetting resin was used to keep the wound open. Second stage curettage was performed when the changes of tumor cavity were not obvious. References | Related Articles | Metrics

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Application of Microdissected Thin Anterolateral Thigh Flap in Oral and Maxillofacial Soft Tissue Defects SUN Libo, LAN Yuyan , ZHOU Hangyu , FU Guangxin, WANG Lei, YAO Zhihao 2020, 36(4): 346-349.  DOI: 10.13701/j.cnki.kqyxyj.2020.04.010 Abstract ( 217 )   PDF (2357KB) ( 271 )   Objective: To explore the application of microdissected thin anterolateral thigh flap in the repair of oral and maxillofacial soft tissue defects. Methods: From December 2015 to May 2018, 56 patients with oral and maxillofacial soft tissue defects were included. Preoperative CT angiography was conducted. Imaging workstations (Philips Medical Systems) were used to locate perforating vessels, design personalized flaps, simulate flaps cutting, and measure the fat thickness of the flaps. For 15 patients with thick subcutaneous fat, the adipose tissue was dissected after verifying the distribution of the blood vessels using an operating microscope. The whole flap was transposed to the recipient areas for microsurgical reparation. Results: 14 flaps survived completely. Only 1 flap suffered partial margin necrosis, which was healed after dressing change. The flap ranged from 9 cm×5 cm to 6 cm×4 cm in size. Donor recipient site was not severe complications, and secondary operative procedure was not needed in any patient in the follow-up. Conclusion: CT angiography can effectively guide the design of anterolateral thigh flap. For patients with thicker subcutaneous fat, microdissected thin anterolateral thigh flap was safe and reliable for patients with oral and maxillofacial soft tissue defects. References | Related Articles | Metrics

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Changes of Tfh Cells in SD Rats Immunized with Periodontitis DNA Vaccine pVAX1-HA2-FimA-(IL-15) through Nasal Mucosa TIAN Yuan, CHEN Jing, ZENG Fengjiao, YU Hang, LIU Xia, LIU Jianguo, BAI Guohui 2020, 36(4): 350-354.  DOI: 10.13701/j.cnki.kqyxyj.2020.04.011 Abstract ( 219 )   PDF (2258KB) ( 154 )   Objective: To investigate the changes of Tfh cells in SD rats immunized with pVAX1-HA2-FimA-(IL- 15) eriodontitis gene vaccine, and to investigate the role of Tfh cells in mucosal immune response to produce specific SIgA antibody. Methods: SD rats were randomly divided into three groups. Group A was nasal saline, group B was nasal drop vector (pVAX1), and group C was nasal drop periodontitis vaccine pVAX1-HA2-FimA-(IL- 15). ELISA was used to detect the level of specific SIgA antibody in rat saliva, immunofluorescence technique was used to detect the localization of Tfh cells in nasal mucosa, and flow cytometry was used to detect Tfh cells in nasal mucosa and CD4+CXCR5+ICOS+Tfh Expression of cells. Results: The expression level of specific SIgA antibody in saliva of group C was always higher than that of group A and group B (P<0.05). The fusion of FITC(CD4) and Aleax flour 594(CXCR5) in group C showed yellow fluorescence, and the double immunofluorescence staining results of group A and group B showed no double positive fluorescence signal. The expression of CD4+CXCR5+Tfh and CD4+CXCR5+ICOS+ Tfh in nasal mucosa of group C rats was higher than those of group A and group B (P<0.05). The specific SIgA in rat saliva and rat nasal mucosa CD4 were found. There were correlations between CD4+CXCR5+Tfh and CD4+CXCR5+ICOS+Tfh cells. Conclusion: pVAX1-HA2-FimA-(IL- 15), a genetic vaccine for periodontitis, can activate the expression of Tfh cells in nasal mucosa after immunizing rats with specific SIgA antibody, and the expression level is positively correlated with the level of specific SIgA antibody, suggesting that Tfh cells may play an important role in promoting the production of specific SIgA antibody in the body. References | Related Articles | Metrics

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Metagenomic Analysis of Microbial Community Profiles in Deep Caries in Different Databases CHANG Ting, ZHOU Mi, LI Yihong, LIU Gaoxia 2020, 36(4): 355-359.  DOI: 10.13701/j.cnki.kqyxyj.2020.04.012 Abstract ( 181 )   PDF (3244KB) ( 358 )   Objective: To explore the annotation distinction of microbial taxa of human deep carious lesion in different databases. Methods: Sixteen deep carious samples were obtained from the first permanent molars of eight young adult patients. High-throughput metagenomic technology was used to sequence the microbial genomic DNA of each sample. The microbial composition and abundance at each taxon level were analyzed with both the NCBI nr database and HOMD database. Results: For the deep carious lesions, whether the NCBI nr database or HOMD database, the top 10 microbial taxa found at class rank were Actinobacteria, Bacilli, Bacteroidetes,Coriobacteriia, Negativicutes, Fusobacteriia, Clostridia, Betaproteobacteria, Flavobacteriia and Synergistia. At the genus rank, the top 10 microbial taxa identified from both databases were Lactobacillus, Actinomyces, Olsenella, Prevotella, Propionibacterium, Streptococcus, Selenomonas, Corynebacterium, Leptotrichia and Parascardovia. The abundance and percentage of the microbial taxa acquired from two databases were similar (P>0.05). Conclusion: The findings demonstrated that there was no significant statistical difference in microbial annotation analysis between the NCBI nr database and HOMD database for deep carious samples. References | Related Articles | Metrics

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Role of Streptococcus Sanguis Bacteriocin on Regulating the Activity of Biofilms of Aggregatibacter Actinomycetemcomitans and Candida Albicans WU Yinxuan, MA Shengli, GE Wenyu, LI Hui, WU Lichun, WANG Xin, LI Chunmei 2020, 36(4): 360-364.  DOI: 10.13701/j.cnki.kqyxyj.2020.04.013 Abstract ( 221 )   PDF (1592KB) ( 230 )   Objective: To study the MIC of streptococcus sanguis bacteriocin on the biofilm of A.a and C.a. and to study the effects of Streptococcus sanguis bacteriocin on the biofilm activity of A.a and mixed cultured A.a and C.a. by laser confocal microscopy. Methods: Through low temperature high speed centrifugation, cell fragmentation, salting out, and other methods, Streptococcus sanguis bacteriocin was extracted. The MIC of A.a and mixed cultured A.a and C.a were determined by double dilution method. The biofilm activity was observed after 2h, 6h, 12h, 24h, 48h, and 72h by laser confocal microscope after the action of Streptococcus sanguis bacteriocin on A.a and mixed cultured A.a and C.a. Results: The MIC of separate A.a was 0.25 g/L. The MIC of separate C.a was 0.125 g/L. The MIC of the mixed cultured A.a and C.a was 0.5 g/L . The results of laser confocal microscope showed that the biofilm activity of A.a was strongly inhibited by streptococcus sanguis bacteriocin. The most significant time was 72 h. The biofilm activity of mixed culture A.a and C.a were also strongly inhibited by Streptococcus sanguis bacteriocin. The most significant time was 48 h. Conclusion: Streptococcus sanguis bacteriocin inhibited the biofilm activity of separate A.a and the mixed cultured A.a and C.a. References | Related Articles | Metrics

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Expression of IL-17 in Chronic Periapical Periodontitis of Deciduous Teeth ZHOU Yan, WANG Yinghui, ZHAO Huanying, SHANG Jiajian. 2020, 36(4): 365-368.  DOI: 10.13701/j.cnki.kqyxyj.2020.04.014 Abstract ( 207 )   PDF (2481KB) ( 149 )   Objective: To detect the expression and distribution of IL-17 in periapical lesions of deciduous teeth and investigate the possible role of IL-17 in the pathogenesis of chronic periapical periodontitis in deciduous teeth. Methods: Tissue samples were collected from 120 deciduous teeth with chronic periapical periodontitis. Histopathological examination was performed to determine the pathological type and the degree of inflammatory cell infiltration. The distribution characteristics and expressions of IL-17 in tissues were detected by immunohistochemistry and ELISA. Results: Periapical granulomas (65.8%) were the most common pathological type in 120 deciduous teeth, followed by periapical cyst (18.4%) and periapical abscess (15.8%). IL-17 was expressed in three pathological types, mainly in lymphocytes and plasma cells. ELISA results showed that the expressions of IL-17 in three pathological types were lower than that in control group and the degree of inflammation was negatively correlated with IL-17 in periapical granulomas. Conclusion: IL-17 was detected widely in periapical lesions of deciduous teeth. Expression of IL-17 gradually decreased with the inflammation progression. IL-17 may contribute to the inhibition of the progression in chronic periapical periodontitis. References | Related Articles | Metrics

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Effect of Piezosurgery on Root-end Surface Roughness in Root Apical Surgery MA Yanqun 2020, 36(4): 369-371.  DOI: 10.13701/j.cnki.kqyxyj.2020.04.015 Abstract ( 189 )   PDF (1327KB) ( 309 )   Objective: To compare the difference in root-end surface roughness after root-end resection by piezosurgery, fissure bur, and diamond bur. Methods: 60 teeth according to inclusion criteria were randomly divided into three groups (piezosurgery group, fissure bur group, and diamond bur group). Then, three group teeth were removed root tip 3mm respectively by piezosurgery , fissure bur, and diamond bur. The root-end surface roughness (Ra) was measured and the surface morphology was observed by microscope. Results: The Ra values of three groups were respectively (0.470±0.071) μm, (0.567±0.100) μm, and (2.354±0.313) μm. Significant difference was found between piezosurgery group and diamond bur group (P<0.01). There was no statistically difference between piezosurgery group and fissure bur group (P>0.05). Conclusion: Compared to traditional fissure bur and diamond bur, root-end resection with piezosurgery in apical surgery will produce smoother root-end surface. References | Related Articles | Metrics

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Effect of Proanthocyanidins on Durability of Dentin Bonding at Different Dentin Depths LIU Wen, LIU Min, DENG Ting, WANG Wen, ZHENG Yuemei, GUO Lin, XIE Cuiliu 2020, 36(4): 372-376.  DOI: 10.13701/j.cnki.kqyxyj.2020.04.016 Abstract ( 205 )   PDF (2732KB) ( 229 )   Objective: To investigate the effect of proanthocyanidins on the durability of dentin bonding at different dentin depths. Methods: 40 third molars were randomly divided into 8 groups (n=5): group A and A1: shallow + 6.5% PA; group B and B1: shallow + ethanol; group C and C1: deep + 6.5% PA; group D and D1: deep + ethanol. Specimens of groups A1, B1, C1 and D1 were conducted aging test. The shear bond strength of all specimens was tested. The fracture mode was counted and the fracture surface morphology was observed under scanning electron microscope. Results: The main effect of "aging", "dentin depth", and "PA" was statistically significance (P<0.05), and the second-order and third-order interaction effects had no statistically significance. The main fracture mode of all groups was mixed fracture. The resin tags of group A1 and C1 were closely filled in dentine tubules, while the dentine tubules and resin of group B1 and D1 appeared to be dissolved. Conclusion: PA can enhance the immediate shear bond strength of dentin and improve the bonding durability. The shear bond strength of deep dentin is lower than that of superficial dentin References | Related Articles | Metrics

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Effect of N-acetylcysteine on Inflammatory Injury Induced by Lipopolysaccharide in Vascular Endothelial Cells ZHANG Zhenzhen, XIONG Ting, ZHENG Rui, HUANG Jialin, GUO Ling 2020, 36(4): 377-381.  DOI: 10.13701/j.cnki.kqyxyj.2020.04.017 Abstract ( 221 )   PDF (886KB) ( 180 )   Objective: To investigate whether N-acetylcysteine (NAC) has protective effects on lipopolysaccharide (LPS)-stimulated vascular endothelial cells, and provide a theoretical basis for the treatment of peri-implantitis and periodontitis. Methods: The effects of different concentrations of LPS or NAC on proliferation of human umbilical vein endothelial cells (HUVECs) were measured by cell counting kit 8 (CCK-8) to obtain the optimal drug concentration for stimulation of HUVECs. After adding the optimal drug concentration of LPS and/or NAC to treat HUVECs for 24 h, real-time semi-quantitative polymerase chain reaction (RT-qPCR) was used to detect the mRNA expression of inflammatory factors interleukin-8 (IL-8), tumor necrosis factor-α (TNF-α), and cell adhesion molecule 1 (ICAM-1). Protein expression of TNF-α and IL-8 were detected by enzyme-linked immunosorbent assay (ELISA). The protein expressions of ICAM-1 and NF-κB signaling pathway were detected by western blot. Results: LPS stimulated HUVECs to overexpress inflammatory factors TNF-α, IL-8, and ICAM-1. In addition, LPS increased phosphorylation of P65 (pP65) expression in the NF-κB pathway. However, NAC pretreatment of HUVECs significantly inhibited the increase of TNF-α, IL-8, and ICAM-1 expression induced by LPS and decreased the secretion level of pP65. Conclusion: NAC protects HUVECs against LPS-mediated inflammatory reaction and alleviates inflammation. The underlying mechanism is related to the NF-κB pathway. References | Related Articles | Metrics

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Observation of Mongersen's Anti-inflammatory Effect on Periodontitis Rat DING Xiaohan, YUE Yiyun, XIA Boyuan, LI Yan, LIU Xinchan, WU Zhou, YU Weixian 2020, 36(4): 382-386.  DOI: 10.13701/j.cnki.kqyxyj.2020.04.018 Abstract ( 232 )   PDF (2124KB) ( 193 )   Objective: To investigate the anti-inflammatory effect of mongersen on periodontitis in rat. Methods: A total of 22 healthy male Wistar rats aged 8 weeks were randomly selected. The models of periodontitis were established in 16 rats which were randomly divided into 3 groups, group M (mongersen), group N (saline), and group C (negative controls), the remaining 6 rats were Group C0 (no intervention). All drugs were injected into the rat's maxillary buccal and palatine side of gingival via a microsyringe. Two weeks later, clinical parameters and morphological analysis were measured, then all rats were sacrificed, and the histological changes of periodontal tissues in each group were observed by HE stain and the expression of inflammatory cytokines in gingival tissues of rats were detected by qRT-PCR. Results: Clinical indicators and histological observation showed that in Group M the inflammation was alleviated compared with the group N and C. The qRT-PCR results showed that the gene expressions of TNF-α, IL-1β, IL-6, and INOS in the group M were significantly decreased compared with those of group N and C (P<0.001). Conclusion: Mongersen has anti-inflammatory effect on periodontitis rat. References | Related Articles | Metrics

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Study on Association between Oral Mucosal Diseases, Oral Symptoms, and Inflammatory Bowel Disease ZHANG Limin, ZHOU Jiamin, ZHANG Han, LU Yunyang, WEI Xiaoyu, ZHANG Xinfang, CHEN Baili, YANG Junying 2020, 36(4): 387-392.  DOI: 10.13701/j.cnki.kqyxyj.2020.04.019 Abstract ( 232 )   PDF (927KB) ( 286 )   Objective: To study the association between activity, duration, and drug therapy of inflammatory bowel disease (IBD) and oral mucosal diseases and oral symptoms. Methods: In this cross-sectional study, questionnaires and oral mucosal examinations were conducted among 389 IBD patients [265 with Crohn’s disease (CD) and 124 with ulcerative colitis (UC)] and 265 healthy controls. Chi-square tests and logistic regression were used to analyse the data. Results: The prevalence of fissured tongue in CD patients was higher than controls (P=0.021), and the risk increased by 7.76 times. Compared with controls, CD and UC patients had higher incidence of xerostomia and halitosis (P<0.05), and the risk of xerostomia increased by 1.98 times and 1.48 times, respectively, and the risk of halitosis increased by 0.96 times and 0.72 times, respectively. Active CD had higher prevalence of recurrent aphthous ulcer and fissured tongue compared with that in remission (P=0.048, P=0.009). The prevalence of oral lichen planus increased over the duration of CD patients (P=0.035). The detection rate of abnormal oral mucosa in CD patients treated with aminosalicylate was higher than that in immunosuppressive patients (P=0.003). Conclusion: Patients with IBD have higher risk of oral mucosal diseases and oral symptoms, which are associated with IBD activity, duration, and drug therapy, and require oral health education and multidisciplinary treatment References | Related Articles | Metrics

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Study on Equtiy of Nursing Human Resource Allocation in Jilin Province ZHANG Jie , ZHANG Tongfei 2020, 36(4): 393-395.  DOI: 10.13701/j.cnki.kqyxyj.2020.04.020 Abstract ( 196 )   PDF (787KB) ( 181 )   Objective: To analyze the present situation and allocation of nursing human resources in stomatological institutions in Jilin Province with aim to provide reference for relevant management departments. Methods: The study was performed by the methods of descriptive analysis, Lorentz curve, and Gini coefficient, etc. Results: The nursing human resources of dental institutions in Jilin Province were seriously insufficient. The allocation was relatively fair and the population distribution was better than the fairness of geographical distribution. However, the waste and shortage of the nursing human resources in the basic dental medical institutions appeared at the same time. Conclusion: The relevant departments should take timely and effective measures to prevent the loss of oral nursing talents, improve the treatment of nursing staff in primary oral health institutions, and optimize and adjust the allocation of oral nursing human resources in Jilin Province under the premise of following the principle of fairness. References | Related Articles | Metrics

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Seven Supernumerary Teech in Premolar Regions: One Case Report HU Yong, ZHAO Dayong, MA Sancheng. 2020, 36(4): 396-397.  DOI: 10.13701/j.cnki.kqyxyj.2020.04.021 Abstract ( 215 )   PDF (2372KB) ( 181 )   Non-syndromic multiple supernumerary teeth in the maxillary and mandibular premolar regions are uncommon. We report a case of seven supernumerary teech in a 30-year-old man’s premolar regions, review the literature on supernumerary teeth, and discuss their etiology, diagnosis, and treatment. References | Related Articles | Metrics

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Application of Straight Incision in Apical Surgery Guided by Three-dimensional Printed Template-A Case Report. TU Xinran, WEN Cheng, YAN Liang, YANG Xuechao, FAN Mingwen, JIANG Qianzhou 2020, 36(4): 398-400.  DOI: 10.13701/j.cnki.kqyxyj.2020.04.022 Abstract ( 237 )   PDF (5212KB) ( 229 )   A patient suffered from periapical periodontitis caused by apical foreign body. A straight incision was made at vestibular groove in order to eliminate the complications caused by flap surgery. A minimally invasive apical surgery was then performed with the three-dimensional printed template. Then the healing of lesion and incision were observed and assessed. References | Related Articles | Metrics