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Study on Association between Oral Mucosal Diseases, Oral Symptoms, and Inflammatory Bowel Disease
ZHANG Limin, ZHOU Jiamin, ZHANG Han, LU Yunyang, WEI Xiaoyu, ZHANG Xinfang, CHEN Baili, YANG Junying
2020, 36(4):
387-392.
DOI: 10.13701/j.cnki.kqyxyj.2020.04.019
Objective: To study the association between activity, duration, and drug therapy of inflammatory bowel disease (IBD) and oral mucosal diseases and oral symptoms. Methods: In this cross-sectional study, questionnaires and oral mucosal examinations were conducted among 389 IBD patients [265 with Crohn’s disease (CD) and 124 with ulcerative colitis (UC)] and 265 healthy controls. Chi-square tests and logistic regression were used to analyse the data. Results: The prevalence of fissured tongue in CD patients was higher than controls (P=0.021), and the risk increased by 7.76 times. Compared with controls, CD and UC patients had higher incidence of xerostomia and halitosis (P<0.05), and the risk of xerostomia increased by 1.98 times and 1.48 times, respectively, and the risk of halitosis increased by 0.96 times and 0.72 times, respectively. Active CD had higher prevalence of recurrent aphthous ulcer and fissured tongue compared with that in remission (P=0.048, P=0.009). The prevalence of oral lichen planus increased over the duration of CD patients (P=0.035). The detection rate of abnormal oral mucosa in CD patients treated with aminosalicylate was higher than that in immunosuppressive patients (P=0.003). Conclusion: Patients with IBD have higher risk of oral mucosal diseases and oral symptoms, which are associated with IBD activity, duration, and drug therapy, and require oral health education and multidisciplinary treatment
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