Research Progress on Factors Influencing the Curative Effect of Photodynamic Therapy for Oral Leukoplakia

doi:10.13701/j.cnki.kqyxyj.2022.04.002

Abstract

Abstract: Oral leukoplakia is defined as the white lesions on the oral mucosa, mainly characterized by hyperkeratosis, which is the most common potential malignant disease of the oral cavity. At present, there are various treatment methods, among which photodynamic therapy as a novel minimally invasive technique with combined use of drugs and devices, is promising and highly feasible in the treatment of oral leukoplakia. In this paper, the basic principle of photodynamic therapy, treatment factors, and relevant factors affecting the efficacy of leukoplakia were reviewed.

Key words: photodynamic therapy, oral leukoplakia

ZHAO Jinjin, CAI Yang. Research Progress on Factors Influencing the Curative Effect of Photodynamic Therapy for Oral Leukoplakia[J]. Journal of Oral Science Research, 2022, 38(4): 304-307.

References

[1] 中华口腔医学会口腔黏膜病专业委员会.口腔白斑病的定义与分级标准(试行)[J].中华口腔医学杂志,2011,46(10):579-580.
[2] 沙桐,张伟.氧化应激对潜在口腔恶性疾病作用的研究进展[J].口腔医学研究,2021,37(2):109-112.
[3] Amagasa T, Yamashiro M, Uzawa N. Oral premalignant lesions: from a clinical perspective[J]. Int J Clin Oncol, 2011, 16(1): 5-14.
[4] Ganesh D, Sreenivasan P, Öhman J, et al. Potentially malignant oral disorders and cancer transformation[J]. Anticancer Res, 2018, 38(6):3223-3229.
[5] 韩晓博,郑英虹,杨力明.光敏剂在光动力治疗中的研究进展[J].上海大学学报(自然科学版),2017,23(2):169-178.
[6] Chen Q, Dan H, Tang F, et al. Photodynamic therapy guidelines for the management of oral leucoplakia[J]. Int J Oral Sci, 2019, 11(2):103-107.
[7] Li Y, Wang B, Zheng S, et al. Photodynamic therapy in the treatment of oral leukoplakia: A systematic review[J]. Photodiagnosis Photodyn Ther, 2019, 25(3): 17-22.
[8] Kwiatkowski S, Knap B, Przystupski D, et al. Photodynamic therapy-mechanisms,photosensitizers and combinations[J]. Biomed Pharmacother, 2018, 106(10):1098-1107.
[9] 李亚楠,王怡乔,潘铁成,等.肿瘤光动力疗法——作用机制[J].中国激光医学杂志,2014,23(1):39-48.
[10] Sorrin AJ, Kemal Ruhi M, Ferlic NA, et al. Photodynamic therapy and the biophysics of the tumor microenvironment[J]. Photochem Photobiol, 2020, 96(2):232-259.
[11] 万勃,邓文婷.光动力疗法的研究进展[J].广东化工,2019,46(7):124-127.
[12] 郑哲,张国龙,王秀丽.单线态氧在光动力治疗中的作用机制及检测方法[J].中国激光医学杂志,2019,28(4):219-223.
[13] Misba L, Zaidi S, Khan AU. Efficacy of photodynamic therapy against Streptococcus mutans,biofilm: Role of singlet oxygen[J]. J Photochem Photobiol B, 2018, 183:16-21.
[14] Kim MM, Penjweini R, Gemmell NR, et al. A comparison of singlet oxygen explicit dosimetry(SOED)and singlet oxygen luminescence dosimetry(SOLD)for photofrin-mediated photodynamic therapy[J]. Cancers (Basel), 2016, 8(12):109.
[15] 董毅,曾昕,陈谦明.光动力治疗与口腔粘膜白斑病[J].临床口腔医学杂志,2005,21(7):442-443.
[16] Ethirajan M, Chen Y, Joshi P, et al. The role of porphyrin chemistry in tumor imaging and photodynamic therapy[J]. Chem Soc Rev, 2010, 40(1):340-362.
[17] Bonnet S. Shifting the light activation of metallodrugs to the red and near-infrared region in anticancer phototherapy[J]. Comments Inorg Chem, 2015, 35:179-213.
[18] 刘宏伟.光动力疗法在口腔黏膜病治疗中的应用[J].中国口腔医学继续教育杂志,2019,22(6):353-357.
[19] Kawczyk-Krupka A, Wakowska J, Raczkowska-Siostrzonek A, et al. Comparison of cryotherapy and photodynamic therapy in treatment of oral leukoplakia[J]. Photodiagnosis Photodyn Ther, 2012, 9(2):148-155.
[20] Maloth KN, Velpula N, Kodangal S, et al. Photodynamic therapy-a non-invasive treatment modality for precancerous lesions[J]. J Lasers Med Sci, 2016, 7(1):30-36.
[21] Shafirstein G, Friedman A, Siegel E, et al. Using 5-aminolevulinic acid and pulsed dye laser for photodynamic treatment of oral leukoplakia[J]. Arch Otolaryngol Head Neck Surg, 2011, 137(11):1117-1123.
[22] Han Y, Xu S, Jin J, et al. Primary clinical evaluation of photodynamic therapy with oral leukoplakia in Chinese patients[J]. Front Physiol, 2019, 22(9): 1911.
[23] Yu CH, Chen HM, Hung HY, et al. Photodynamic therapy outcome for oral verrucous hyperplasia depends on the clinical appearance, size, color, epithelial dysplasia, and surface keratin thickness of the lesion[J]. Oral Oncol, 2008, 44(6):595-600.
[24] Togsverd-Bo K, Haak CS, Thaysen-Petersen D, et al. Intensified photodynamic therapy of actinic keratoses with fractional CO₂ laser: a randomized clinical trial[J]. Br J Dermatol, 2012, 166(6):1262-1269.
[25] Wang X, Han Y, Jin J, et al. Plum-blossom needle assisted photodynamic therapy: The therapy option for the treatment of oral potentially malignant disorder in the elderly[J]. Photodiagnosis Photodyn Ther, 2019, 25(3):296-299.
[26] Jin X, Xu H, Deng J, et al. Photodynamic therapy for oral potentially malignant disorders[J]. Photodiagnosis Photodyn Ther, 2019, 28: 146-152.
[27] Fan KF, Hopper C, Speight PM, et al. Photodynamic therapy using 5-aminolevulinic acid for premalignant and malignant lesions of the oral cavity[J]. Cancer, 2015, 78(7):1374-1383.
[28] Chen HM, Yu CH, Tu PC, et al. Successful treatment of oral verrucous hyperplasia and oral leukoplakia with topical 5-aminolevulinic acid-mediated photodynamic therapy[J]. Lasers Surg Med, 2005, 37(2):114-122.
[29] Kübler A, Haase T, Rheinwald M, et al. Treatment of oral leukoplakia by topical application of 5-aminolevulinic acid[J]. Int J Oral Maxillofac Surg, 1998, 27(6):466-469.
[30] Selvam NP, Sadaksharam J, Singaravelu G, et al. Treatment of oral leukoplakia with photodynamic therapy: A pilot study[J]. J Cancer Res Ther, 2015, 11(2):464-467.
[31] Prasanna SW, Ingle E, Aruna PR, et al. Photodynamic therapy of oral leukoplakia and oral lichen planus using methylene blue: A pilot study[J]. J Innov Opt Health SCI, 2015, 811(1):1540005.
[32] Pietruska M , Sobaniec S, Bernaczyk P ,et al. Clinical evaluation of photodynamic therapy efficacy in the treatment of oral leukoplakia[J]. Photodiagnosis Photodyn Ther, 2014, 11(1):34-40.
[33] Chen HM, Yu CH, Tsai T, et al. Topical 5-aminolevulinic acid-mediated photodynamic therapy for oral verrucous hyperplasia, oral leukoplakia and oral erythroleukoplakia[J]. Photodiagnosis Photodyn Ther, 2007, 4(1):44-52.