Abstract: Objective: To retrospectively analyze 9 patients with anterior lingual gland tumors, and discuss their clinical characteristics, treatment strategies, and prognosis. Methods: Between November 2010 and November 2023, 1619 patients with “tongue malignancy” were admitted to the Department of Oral and Maxillofacial Surgery of the Affiliated Stomatological Hospital of the School of Medicine of Nanjing University (Nanjing Stomatological Hospital).All of them underwent surgical treatments, and 9 of them had malignant tumors of the anterior lingual glands, which were retrospectively analyzed. A retrospective analysis of these lesions was performed. Results: Among 9 patients, 4 cases were adenoid cystic carcinoma, 4 cases were mucoepidermoid carcinoma, and 1 case was clear cell carcinoma.Those with small tissue defects were directly pulled together and sutured, and those with large tissue defects were repaired with flaps: 4 cases of forearm flap, 1 case of lateral muscle flap of the upper arm, and 1 case of under-chin island flap.The prognosis of all patients was good. Conclusion: Although the incidence of anterior lingual glandtumors is relatively low, once developed, its malignant degree is often high, with adenoid cystic carcinoma, mucoepidermoid carcinoma, and clear cell carcinoma as the main types. The clinical manifestation is a well-demarcated mass in the abdomen of the tip of the tongue, with moderately hard texture and poor mobility. Surgical resection is the treatment of choice for anterior lingual gland tumors, and the decision of postoperative adjuvant therapy is based on the specific nature of the tumor and the specifics of the surgery.

Key words: anterior lingual gland, adenoid cystic carcinoma, mucoepidermoid carcinoma, clear cell carcinoma